{"id":"usual-dose-treatment-of-tandospirone","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tandospirone selectively binds to and activates 5-HT1A receptors, which are G-protein coupled receptors involved in mood regulation and anxiety control. By acting as a partial agonist at these receptors, it increases serotonergic activity in brain regions associated with anxiety and depression, leading to anxiolytic and antidepressant effects. This mechanism is distinct from selective serotonin reuptake inhibitors (SSRIs) as it directly activates the receptor rather than blocking reuptake.","oneSentence":"Tandospirone is a serotonin 1A (5-HT1A) receptor agonist that enhances serotonergic neurotransmission in the central nervous system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:38:18.693Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Generalized anxiety disorder"},{"name":"Major depressive disorder"}]},"trialDetails":[{"nctId":"NCT01614041","phase":"PHASE4","title":"Tandospirone Citrate in the Treatment of Patients With Generalized Anxiety Disorder","status":"COMPLETED","sponsor":"Sumitomo Pharma (Suzhou) Co., Ltd.","startDate":"2012-01-10","conditions":"Generalized Anxiety Disorder","enrollment":274}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Usual dose treatment of Tandospirone","genericName":"Usual dose treatment of Tandospirone","companyName":"Sumitomo Pharma (Suzhou) Co., Ltd.","companyId":"sumitomo-pharma-suzhou-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tandospirone is a serotonin 1A (5-HT1A) receptor agonist that enhances serotonergic neurotransmission in the central nervous system. Used for Generalized anxiety disorder, Major depressive disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}