{"id":"usual-brand-cigar","safety":{"commonSideEffects":[{"rate":"null","effect":"Nicotine withdrawal symptoms"},{"rate":"null","effect":"Cardiovascular disease"},{"rate":"null","effect":"Lung cancer"},{"rate":"null","effect":"Respiratory disease"}]},"_chembl":{"chemblId":"CHEMBL1200500","moleculeType":"Small molecule","molecularWeight":"521.05"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Nicotine binds to nicotinic acetylcholine receptors, stimulating the release of dopamine and other neurotransmitters, which can lead to feelings of pleasure and reward. This can lead to physical dependence and addiction. The effects of nicotine on the brain can also lead to changes in mood, attention, and other cognitive processes.","oneSentence":"Usual brand cigar is a tobacco product that contains nicotine, which acts on nicotinic acetylcholine receptors in the brain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:38:13.171Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation"}]},"trialDetails":[{"nctId":"NCT06630728","phase":"PHASE4","title":"Addiction Potential of Very Low Nicotine Filtered Little Cigars","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2025-02-13","conditions":"Smoking (Tobacco) Addiction","enrollment":50},{"nctId":"NCT04844762","phase":"NA","title":"Addiction and Behavior Related to Menthol Cigarette Substitutes","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2019-12-16","conditions":"Smoking (Tobacco) Addiction","enrollment":120},{"nctId":"NCT02000921","phase":"NA","title":"Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2013-12","conditions":"Tobacco Addiction, Dual Tobacco Use","enrollment":136}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["UB"],"phase":"marketed","status":"active","brandName":"Usual brand cigar","genericName":"Usual brand cigar","companyName":"Ohio State University Comprehensive Cancer Center","companyId":"ohio-state-university-comprehensive-cancer-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Usual brand cigar is a tobacco product that contains nicotine, which acts on nicotinic acetylcholine receptors in the brain. Used for Smoking cessation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}