{"id":"usage-of-fibrin-sealant","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Thrombosis (rare)"},{"rate":null,"effect":"Immunogenicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Fibrin sealant is a topical hemostatic agent composed of fibrinogen (or fibrin) and thrombin that mimics the final stages of the coagulation cascade. When applied to a bleeding surface, thrombin converts fibrinogen into fibrin monomers, which polymerize and cross-link to form a stable clot. This provides rapid hemostasis and can also serve as a tissue adhesive and scaffold for wound healing.","oneSentence":"Fibrin sealant forms a hemostatic plug by combining fibrinogen and thrombin to create a cross-linked fibrin clot that seals wounds and stops bleeding.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:17.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis and sealing of surgical wounds"},{"name":"Topical bleeding control during surgical procedures"},{"name":"Tissue adhesion and wound healing support"}]},"trialDetails":[{"nctId":"NCT07455591","phase":"PHASE4","title":"A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement","status":"COMPLETED","sponsor":"Singapore General Hospital","startDate":"2024-01-01","conditions":"Osteo Arthritis of the Knee","enrollment":78},{"nctId":"NCT05385952","phase":"NA","title":"GATT-Patch Versus TachoSil in Liver Surgery","status":"COMPLETED","sponsor":"GATT Technologies BV","startDate":"2022-08-04","conditions":"Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases","enrollment":132},{"nctId":"NCT06319287","phase":"PHASE2","title":"Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)","status":"COMPLETED","sponsor":"Rion Inc.","startDate":"2024-02-27","conditions":"Diabetic Foot Ulcer","enrollment":59},{"nctId":"NCT02307916","phase":"PHASE2","title":"Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations","status":"COMPLETED","sponsor":"D. 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