{"id":"urea-cream-based","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning sensation"},{"rate":null,"effect":"Transient erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Urea penetrates the outer layer of skin and disrupts hydrogen bonds between keratin filaments, thereby softening and loosening dead skin cells. Simultaneously, it functions as a humectant by drawing moisture into the epidermis, which enhances hydration and promotes skin healing. This dual action makes it effective for conditions characterized by abnormal keratinization and xerosis.","oneSentence":"Urea cream acts as a keratolytic and humectant agent that softens and hydrates the stratum corneum, facilitating removal of hyperkeratotic tissue and improving skin barrier function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:08.048Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hyperkeratotic skin conditions"},{"name":"Xerosis and dry skin disorders"},{"name":"Ichthyosis and related keratinization disorders"}]},"trialDetails":[{"nctId":"NCT03813407","phase":"PHASE3","title":"An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2019-04-02","conditions":"Hyperkalaemia","enrollment":140},{"nctId":"NCT05939726","phase":"NA","title":"Efficacy and Safety of Moisturising Cream With or Without Vitamin E and Urea 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Paromomycin for Cutaneous Leishmaniasis in Bolivia","status":"COMPLETED","sponsor":"Fundacion Nacional de Dermatologia","startDate":"2017-04-15","conditions":"Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex, Leishmaniasis, American","enrollment":80},{"nctId":"NCT02247830","phase":"PHASE3","title":"Management Radiodermatitis in Patients With Breast or Head and Neck Cancer","status":"COMPLETED","sponsor":"University of Brasilia","startDate":"2015-07","conditions":"Radiodermatitis","enrollment":48},{"nctId":"NCT04568330","phase":"NA","title":"Prevention of Hand-foot Skin Reaction","status":"COMPLETED","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2014-03-21","conditions":"Hepatocellular Carcinoma","enrollment":129},{"nctId":"NCT00296036","phase":"PHASE3","title":"Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer","status":"COMPLETED","sponsor":"Alliance for 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Used for Hyperkeratotic skin conditions, Xerosis and dry skin disorders, Ichthyosis and related keratinization disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}