{"id":"upacicalcet","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Extracellular calcium-sensing receptor","category":"target"},{"label":"CASR","category":"gene"},{"label":"Active","category":"status"},{"label":"Secondary hyperparathyroidism","category":"indication"},{"label":"SANWA KAGAKU KENKYUSHO Co., Ltd.","category":"company"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"SANWA KAGAKU KENKYUSHO Co., Ltd.","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=UPACICALCET","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:19:12.549936+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Upacicalcet","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:19:20.159023+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:19:18.679151+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=UPACICALCET","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:19:19.059004+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6068421/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:19:19.799842+00:00"}},"allNames":"upasita","offLabel":[],"synonyms":["upacicalcet","upacicalcet sodium hydrate","upasita"],"timeline":[{"date":"2021-06-23","type":"positive","source":"DrugCentral","milestone":"PMDA approval (SANWA KAGAKU KENKYUSHO Co., Ltd.)"}],"approvals":[{"date":"2021-06-23","orphan":false,"company":"SANWA KAGAKU KENKYUSHO Co., Ltd.","regulator":"PMDA"}],"brandName":"Upasita","ecosystem":[{"indication":"Secondary hyperparathyroidism","otherDrugs":[{"name":"etelcalcetide","slug":"etelcalcetide","company":"Kai Pharms Inc"}],"globalPrevalence":null}],"mechanism":{"target":"Extracellular calcium-sensing receptor","targets":[{"gene":"CASR","source":"DrugCentral","target":"Extracellular calcium-sensing receptor","protein":"Extracellular calcium-sensing receptor"}],"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Upasita acts as a negative allosteric modulator of the extracellular calcium-sensing receptor, reducing its sensitivity to calcium ions and thereby decreasing parathyroid hormone secretion."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Upacicalcet","title":"Upacicalcet","extract":"Upacicalcet is a drug used to treat secondary hyperparathyroidism (SHPT) - a disease of the parathyroid gland - in dialysis patients. It was approved as Upasita in Japan in June 2021. The drug is given intravenously. The active ingredient is used in the form of its sodium salt."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5482","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=UPACICALCET","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Upacicalcet","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T16:06:29.550920","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:19:21.531796+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"cinacalcet","drugSlug":"cinacalcet","fdaApproval":"2004-03-08","patentExpiry":"Sep 22, 2026","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"etelcalcetide","drugSlug":"etelcalcetide","fdaApproval":"2017-02-07","patentExpiry":"Jun 27, 2034","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"tryptophan","drugSlug":"tryptophan","fdaApproval":"","relationship":"same-target"}],"genericName":"upacicalcet","indications":{"approved":[{"name":"Secondary hyperparathyroidism","source":"DrugCentral","snomedId":91478007,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cinacalcet","brandName":"cinacalcet","genericName":"cinacalcet","approvalYear":"2004","relationship":"same-target"},{"drugId":"etelcalcetide","brandName":"etelcalcetide","genericName":"etelcalcetide","approvalYear":"2017","relationship":"same-target"},{"drugId":"tryptophan","brandName":"tryptophan","genericName":"tryptophan","approvalYear":"","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"5C1222PBE2","INN_ID":"10796","UMLSCUI":"C5238141","chemblId":"CHEMBL6068421","KEGG_DRUG":"D11564","PUBCHEM_CID":"53374467","IUPHAR_LIGAND_ID":"12235","MESH_SUPPLEMENTAL_RECORD_UI":"C000721071"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"present","companyName":"SANWA KAGAKU KENKYUSHO Co., Ltd.","relationship":"Current Owner"}],"publicationCount":18,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"SANWA KAGAKU KENKYUSHO Co., Ltd.","companyId":"sanwa-kagaku-kenkyusho-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"JP","regulator":"PMDA","status":"approved","approval_date":"2021-06-23T00:00:00.000Z","mah":"SANWA KAGAKU KENKYUSHO Co., Ltd.","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:19:21.531796+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}