{"id":"unsupervised-primaquine-treatment","safety":{"commonSideEffects":[{"rate":null,"effect":"Hemolytic anemia (in G6PD-deficient patients)"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Methemoglobinemia"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL455150","moleculeType":"Small molecule","molecularWeight":"404.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Primaquine acts as a prodrug that is metabolized in the liver to active metabolites capable of generating free radicals within malaria parasites. These reactive oxygen species cause oxidative damage to parasite DNA, proteins, and organelles, leading to parasite death. It is particularly effective against hypnozoites (dormant liver stages) of P. vivax and P. ovale, making it the only widely available drug that can prevent relapse malaria.","oneSentence":"Primaquine is an 8-aminoquinoline antimalarial that eliminates malaria parasites by generating reactive oxygen species that damage parasite DNA and mitochondria.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:37:28.823Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria caused by Plasmodium vivax or Plasmodium ovale (radical cure and relapse prevention)"},{"name":"Malaria caused by Plasmodium falciparum (gametocytocidal activity)"}]},"trialDetails":[{"nctId":"NCT05044637","phase":"PHASE2","title":"Study to Evaluate Primaquine for Radical Cure of Uncomplicated Plasmodium Vivax Malaria in Children","status":"COMPLETED","sponsor":"Fundação de Medicina Tropical Dr. Heitor Vieira Dourado","startDate":"2021-08-26","conditions":"Malaria, Vivax","enrollment":100},{"nctId":"NCT04411836","phase":"PHASE3","title":"Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine","status":"COMPLETED","sponsor":"Menzies School of Health Research","startDate":"2021-04-25","conditions":"Vivax Malaria, Plasmodium Vivax, Malaria, Vivax","enrollment":960},{"nctId":"NCT03610399","phase":"NA","title":"Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2018-04-09","conditions":"P Vivax, Malaria, Vivax","enrollment":257},{"nctId":"NCT02787070","phase":"PHASE4","title":"A Randomized Controlled Trial on Malaria Primaquine Treatment in Timika, Indonesia (TRIPI)","status":"COMPLETED","sponsor":"Menzies School of Health Research","startDate":"2016-09-14","conditions":"Uncomplicated Malaria","enrollment":420},{"nctId":"NCT02793388","phase":"PHASE4","title":"A Trial on Supervised Primaquine Use in Ethiopia","status":"WITHDRAWN","sponsor":"Menzies School of Health Research","startDate":"2016-09","conditions":"Malaria","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Unsupervised primaquine treatment","genericName":"Unsupervised primaquine treatment","companyName":"Menzies School of Health Research","companyId":"menzies-school-of-health-research","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Primaquine is an 8-aminoquinoline antimalarial that eliminates malaria parasites by generating reactive oxygen species that damage parasite DNA and mitochondria. Used for Malaria caused by Plasmodium vivax or Plasmodium ovale (radical cure and relapse prevention), Malaria caused by Plasmodium falciparum (gametocytocidal activity).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}