{"id":"unrestricted-fentanyl","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and modulating emotional responses to pain. It is approximately 50-100 times more potent than morphine. The term 'Unrestricted Fentanyl' likely refers to a formulation or research context without standard regulatory restrictions, though the underlying mechanism remains opioid receptor agonism.","oneSentence":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:37:32.694Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute and chronic pain"},{"name":"Cancer pain"},{"name":"Perioperative anesthesia and analgesia"}]},"trialDetails":[{"nctId":"NCT02734940","phase":"PHASE4","title":"Multimodal Analgesia in Cardiac Surgery (Pilot Study)","status":"TERMINATED","sponsor":"Virginia Commonwealth University","startDate":"2016-07-11","conditions":"Heart Diseases","enrollment":3}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Unlimited intraoperative opiates"],"phase":"marketed","status":"active","brandName":"Unrestricted Fentanyl","genericName":"Unrestricted Fentanyl","companyName":"Virginia Commonwealth University","companyId":"virginia-commonwealth-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Moderate to severe acute and chronic pain, Cancer pain, Perioperative anesthesia and analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}