{"id":"unithiol","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antidotes","category":"pharmacology"},{"label":"Chelating Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Sequestering Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dimaval","offLabel":[],"synonyms":["unithiol","dimaval","unitiol"],"timeline":[],"approvals":[],"brandName":"Dimaval","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Think of Dimaval like a molecular 'glue' that sticks to heavy metal ions, preventing them from interacting with and harming cells. This helps to reduce the toxic effects of heavy metals in the body, allowing for their safe removal. By binding to these ions, Dimaval helps to restore balance and prevent further damage.","oneSentence":"Dimaval works by binding to and neutralizing heavy metal ions, preventing them from causing cellular damage.","technicalDetail":"Dimaval (unithiol) is a thiol-containing compound that forms stable complexes with heavy metal ions, such as mercury and arsenic, through covalent bonding, thereby sequestering and neutralizing their toxic effects."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/2%2C3-Dimercapto-1-propanesulfonic_acid","title":"2,3-Dimercapto-1-propanesulfonic acid","extract":"2,3-Dimercapto-1-propanesulfonic acid and its sodium salt are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating agent."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2792","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=unithiol","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=unithiol","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/2%2C3-Dimercapto-1-propanesulfonic_acid","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T16:11:35.598687","biosimilars":[],"competitors":[],"genericName":"unithiol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07500233","phase":"PHASE2","title":"Trial of Oral Community SVMP INhibitors for Snakebite","status":"NOT_YET_RECRUITING","sponsor":"Liverpool School of Tropical Medicine","startDate":"2027-01","conditions":["Snakebite"],"enrollment":504,"completionDate":"2028-12"},{"nctId":"NCT03957720","phase":"EARLY_PHASE1","title":"The Individual Therapy for Patients With Wilson's Disease","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2019-03-15","conditions":["Wilson's Disease"],"enrollment":400,"completionDate":"2024-12-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166485","NDDF":"006186","UNII":"086L82361J","RXNORM":"10991","UMLSCUI":"C0041738","DRUGBANK_ID":"DB15967","PUBCHEM_CID":"2724039","SNOMEDCT_US":"441993002","MESH_DESCRIPTOR_UI":"D014494"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":225,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dimaval, also known as 2,3-dimercapto-1-propanesulfonic acid, is a chelating agent that forms complexes with various heavy metals. It has been studied in clinical trials for the treatment of snakebite and Wilson's Disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}