{"id":"umeclidinium-bromide-umec","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Urinary retention"}]},"_chembl":null,"_dailymed":{"setId":"b5a81d5a-4648-4c7a-951d-33c014a63c7e","title":"TRELEGY ELLIPTA (FLUTICASONE FUROATE, UMECLIDINIUM BROMIDE AND VILANTEROL TRIFENATATE) POWDER [GLAXOSMITHKLINE LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Umeclidinium is an inhaled anticholinergic agent that selectively antagonizes muscarinic M3 receptors on airway smooth muscle cells. By blocking acetylcholine-mediated bronchoconstriction, it produces sustained bronchodilation and improves lung function in obstructive airway diseases. 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Plus Tiotropium (TIO) in Inadequately Controlled Asthma","status":"WITHDRAWN","sponsor":"GlaxoSmithKline","startDate":"2019-01-18","conditions":"Asthma","enrollment":""},{"nctId":"NCT02164513","phase":"PHASE3","title":"A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-06-30","conditions":"Pulmonary Disease, Chronic Obstructive","enrollment":10355},{"nctId":"NCT02799784","phase":"PHASE4","title":"An Efficacy Study of Umeclidinium/Vilanterol With Tiotropium/Olodaterol in COPD Patients","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-07-14","conditions":"Pulmonary Disease, Chronic Obstructive","enrollment":236},{"nctId":"NCT02236611","phase":"PHASE4","title":"A 12-week Study to Evaluate the Efficacy and 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