{"id":"ugn-104","safety":{"commonSideEffects":[{"rate":"null","effect":"Cystitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The active metabolite of UGN-104 is a thymine analog that intercalates into DNA, thereby inhibiting thymidine synthase and DNA synthesis in cancer cells. This leads to the induction of apoptosis and inhibition of cancer cell proliferation.","oneSentence":"UGN-104 is a synthetic, small molecule that acts as a prodrug, which is converted into its active metabolite in the bladder.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:54:39.029Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Non-muscle invasive bladder cancer"}]},"trialDetails":[{"nctId":"NCT06774131","phase":"PHASE3","title":"A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer","status":"RECRUITING","sponsor":"UroGen Pharma Ltd.","startDate":"2025-08-06","conditions":"Upper Urinary Tract Urothelial Carcinoma, Urothelial Carcinoma","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["UGN-104 (mitomycin) for pyelocalyceal solution"],"phase":"phase_3","status":"active","brandName":"UGN-104","genericName":"UGN-104","companyName":"UroGen Pharma Ltd.","companyId":"urogen-pharma-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"UGN-104 is a synthetic, small molecule that acts as a prodrug, which is converted into its active metabolite in the bladder. Used for Non-muscle invasive bladder cancer.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}