{"id":"uft-uracil-tegafur","safety":{"commonSideEffects":[{"rate":null,"effect":"Bone marrow suppression (leukopenia, thrombocytopenia)"},{"rate":null,"effect":"Gastrointestinal toxicity (nausea, diarrhea, stomatitis)"},{"rate":null,"effect":"Hand-foot syndrome"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tegafur is a prodrug of 5-fluorouracil (5-FU) that is converted in the body to the active form. Uracil is included to inhibit dihydropyrimidine dehydrogenase, the enzyme responsible for 5-FU catabolism, thereby increasing and prolonging 5-FU exposure. Together, they act as a fluoropyrimidine antimetabolite that disrupts nucleotide synthesis and DNA replication in rapidly dividing cancer cells.","oneSentence":"UFT is a combination of uracil and tegafur that inhibits thymidylate synthase to block DNA synthesis and induce cancer cell death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:52:11.017Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Colorectal cancer"},{"name":"Gastric cancer"},{"name":"Breast cancer"}]},"trialDetails":[{"nctId":"NCT00905047","phase":"PHASE3","title":"Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer","status":"COMPLETED","sponsor":"Centre Oscar Lambret","startDate":"2005-11-14","conditions":"Colorectal Cancer","enrollment":89},{"nctId":"NCT07372300","phase":"PHASE3","title":"Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal 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