{"id":"uft-calcium-folinate","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Diarrhea"},{"rate":"10-30%","effect":"Nausea"},{"rate":"5-20%","effect":"Vomiting"},{"rate":"5-20%","effect":"Mucositis"},{"rate":"5-20%","effect":"Leukopenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Calcium folinate is used to counteract the toxic effects of 5-fluorouracil on the bone marrow and mucosa. It works by replenishing folate stores and helping to maintain normal DNA synthesis.","oneSentence":"UFT is a prodrug that is converted into 5-fluorouracil, which inhibits thymidylate synthase, leading to DNA damage and cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:54:39.042Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Colorectal cancer"},{"name":"Gastric cancer"}]},"trialDetails":[{"nctId":"NCT00004860","phase":"PHASE2","title":"Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer","status":"COMPLETED","sponsor":"Eastern Cooperative Oncology Group","startDate":"2000-10-09","conditions":"Colorectal Cancer","enrollment":""},{"nctId":"NCT00660894","phase":"PHASE3","title":"Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery","status":"COMPLETED","sponsor":"Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan","startDate":"2008-04","conditions":"Colorectal Cancer","enrollment":1535},{"nctId":"NCT00002801","phase":"PHASE1","title":"Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"1996-04","conditions":"Colorectal Cancer","enrollment":30},{"nctId":"NCT00009815","phase":"PHASE1","title":"Combination Chemotherapy in Treating Patients With Advanced Solid Tumors","status":"WITHDRAWN","sponsor":"University of Pittsburgh","startDate":"1999-12","conditions":"Unspecified Adult Solid Tumor, Protocol Specific","enrollment":""},{"nctId":"NCT00009828","phase":"PHASE1","title":"Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors","status":"WITHDRAWN","sponsor":"University of Pittsburgh","startDate":"1999-12","conditions":"Unspecified Adult Solid Tumor, Protocol Specific","enrollment":""},{"nctId":"NCT00003925","phase":"PHASE1","title":"Combination Chemotherapy In Treating Patients With Advanced Cancer","status":"COMPLETED","sponsor":"Barbara Ann Karmanos Cancer Institute","startDate":"1998-05","conditions":"Unspecified Adult Solid Tumor, Protocol Specific","enrollment":36},{"nctId":"NCT00385970","phase":"PHASE3","title":"A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer","status":"UNKNOWN","sponsor":"Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group","startDate":"2006-03","conditions":"Colorectal Cancer","enrollment":380},{"nctId":"NCT00005608","phase":"PHASE2","title":"Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2000-02","conditions":"Breast Cancer","enrollment":""},{"nctId":"NCT00378716","phase":"PHASE3","title":"Combination Chemotherapy in Treating Patients With Resected Colon Cancer","status":"COMPLETED","sponsor":"NSABP Foundation Inc","startDate":"1997-02","conditions":"Colorectal Cancer","enrollment":1608},{"nctId":"NCT00677612","phase":"PHASE1, PHASE2","title":"Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Colorectal Cancer","status":"TERMINATED","sponsor":"Tokyo University","startDate":"2008-05","conditions":"Colorectal Cancer, Colon Cancer, Rectal Cancer","enrollment":14},{"nctId":"NCT00677287","phase":"PHASE1, PHASE2","title":"Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in Patients With Colorectal Cancer","status":"TERMINATED","sponsor":"Tokyo University","startDate":"2008-05","conditions":"Colorectal Cancer, Colon Cancer, Rectal Cancer","enrollment":14},{"nctId":"NCT00497107","phase":"PHASE3","title":"Uracil and Tegafur/Leucovorin (UFT/LV) Versus UFT/LV+ Polysaccharide-K (PSK) for Stage IIIa/IIIb Colorectal Cancer","status":"UNKNOWN","sponsor":"Iwate Medical University","startDate":"2007-07","conditions":"Colorectal Cancer","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":28,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"UFT, Calcium Folinate","genericName":"UFT, Calcium Folinate","companyName":"Iwate Medical University","companyId":"iwate-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcium Folinate is a small molecule with an unknown mechanism of action. It is used in combination with other chemotherapy agents, such as 5-fluorouracil and leucovorin calcium, to treat conditions including colorectal cancer, breast cancer, and unspecified adult solid tumors.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}