{"id":"tyrothricin","rwe":[{"pmid":"41595705","year":"2026","title":"Potential Molecular Targets of the Broad-Range Antimicrobial Peptide Tyrothricin in the Apicomplexan Parasite Toxoplasma gondii.","finding":"","journal":"Biomedicines","studyType":"Clinical Study"},{"pmid":"40899887","year":"2025","title":"[Treatment of acute tonsillopharyngitis in elderly patients: aspects of complex topical therapy].","finding":"","journal":"Vestnik otorinolaringologii","studyType":"Clinical Study"},{"pmid":"39471310","year":"2025","title":"Over-the-counter antibiotics compromising aminoglycoside activity.","finding":"","journal":"The Journal of antimicrobial chemotherapy","studyType":"Clinical Study"},{"pmid":"39451299","year":"2024","title":"An Overview of Microorganisms Immobilized in a Gel Structure for the Production of Precursors, Antibiotics, and Valuable Products.","finding":"","journal":"Gels (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"36404690","year":"2022","title":"[Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx].","finding":"","journal":"Vestnik otorinolaringologii","studyType":"Clinical Study"}],"tags":[{"label":"tyrothricin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D06AX08","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tirotrisin","offLabel":[],"synonyms":["tyrothricin","tirotrisin","tyrothricine","tyrotricin"],"timeline":[],"approvals":[],"brandName":"Tirotrisin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"tyrothricin","explanation":"Imagine your body's cells are like factories that make proteins to keep you healthy. Bacteria are like tiny factories that make proteins to harm you. Tirotrisin is a special molecule that blocks the bacterial factories from making proteins, effectively stopping the infection.","oneSentence":"Tirotrisin works by binding to the bacterial ribosome and inhibiting protein synthesis.","technicalDetail":"Tirotrisin binds to the 30S subunit of the bacterial ribosome, specifically targeting the A-site, and inhibits the translocation of peptidyl-tRNA, thereby preventing peptide bond formation and ultimately halting protein synthesis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4739","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TYROTHRICIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TYROTHRICIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:05:48.639262","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:49:04.257292+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"chloramphenicol","drugSlug":"chloramphenicol","fdaApproval":"1950-12-08","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"neomycin","drugSlug":"neomycin","fdaApproval":"1957-03-26","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bacitracin","drugSlug":"bacitracin","fdaApproval":"1948-07-29","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"gentamicin","drugSlug":"gentamicin","fdaApproval":"1970-06-19","genericCount":36,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mupirocin","drugSlug":"mupirocin","fdaApproval":"1987-12-31","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"virginiamycin","drugSlug":"virginiamycin","fdaApproval":"","relationship":"same-class"},{"drugName":"rifaximin","drugSlug":"rifaximin","fdaApproval":"2004-05-25","patentExpiry":"Sep 2, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"amikacin","drugSlug":"amikacin","fdaApproval":"1981-01-22","patentExpiry":"May 15, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"retapamulin","drugSlug":"retapamulin","fdaApproval":"2007-04-12","patentExpiry":"Feb 14, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ozenoxacin","drugSlug":"ozenoxacin","fdaApproval":"2017-12-11","patentExpiry":"Jan 29, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"rifamycin","drugSlug":"rifamycin","fdaApproval":"2018-11-16","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"tyrothricin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chloramphenicol","brandName":"chloramphenicol","genericName":"chloramphenicol","approvalYear":"1950","relationship":"same-class"},{"drugId":"neomycin","brandName":"neomycin","genericName":"neomycin","approvalYear":"1957","relationship":"same-class"},{"drugId":"bacitracin","brandName":"bacitracin","genericName":"bacitracin","approvalYear":"1948","relationship":"same-class"},{"drugId":"gentamicin","brandName":"gentamicin","genericName":"gentamicin","approvalYear":"1970","relationship":"same-class"},{"drugId":"mupirocin","brandName":"mupirocin","genericName":"mupirocin","approvalYear":"1987","relationship":"same-class"},{"drugId":"virginiamycin","brandName":"virginiamycin","genericName":"virginiamycin","approvalYear":"","relationship":"same-class"},{"drugId":"rifaximin","brandName":"rifaximin","genericName":"rifaximin","approvalYear":"2004","relationship":"same-class"},{"drugId":"amikacin","brandName":"amikacin","genericName":"amikacin","approvalYear":"1981","relationship":"same-class"},{"drugId":"retapamulin","brandName":"retapamulin","genericName":"retapamulin","approvalYear":"2007","relationship":"same-class"},{"drugId":"ozenoxacin","brandName":"ozenoxacin","genericName":"ozenoxacin","approvalYear":"2017","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06859281","phase":"PHASE1","title":"Safety, Tolerability, and Pharmacokinetic Profile of Grammidin, a Metered Dose Topical Spray in Healthy Volunteers","status":"RECRUITING","sponsor":"Valenta Pharm JSC","startDate":"2024-12-10","conditions":["Pharyngitis"],"enrollment":24,"completionDate":"2026-12-01"},{"nctId":"NCT06857890","phase":"PHASE1","title":"Safety, Tolerability, and Pharmacokinetic Profile of Grammidin With Anesthetic, a Metered Dose Topical Spray in Healthy Volunteers","status":"RECRUITING","sponsor":"Valenta Pharm JSC","startDate":"2024-12-09","conditions":["Pharyngitis"],"enrollment":24,"completionDate":"2026-12-01"},{"nctId":"NCT03323528","phase":"PHASE4","title":"Safety and Efficacy of a Sore Throat Lozenge DORITHRICIN in Patients With Acute Pharyngitis","status":"COMPLETED","sponsor":"Medice Arzneimittel Pütter GmbH & Co KG","startDate":"2017-02-01","conditions":["Pharyngitis"],"enrollment":321,"completionDate":"2017-11-15"},{"nctId":"NCT00990392","phase":"NA","title":"Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections","status":"WITHDRAWN","sponsor":"Fraser Health","startDate":"2009-11","conditions":["Blood Stream Infections","Skin Diseases, Infectious"],"enrollment":0,"completionDate":"2011-01"},{"nctId":"NCT00534391","phase":"PHASE3","title":"Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage","status":"UNKNOWN","sponsor":"Chulalongkorn University","startDate":"2007-09","conditions":["Hordeolum"],"enrollment":120,"completionDate":"2008-12"},{"nctId":"NCT01227759","phase":"PHASE2","title":"Tyrosur® Gel-Investigation on Wound Healing Efficacy","status":"COMPLETED","sponsor":"Engelhard Arzneimittel GmbH & Co.KG","startDate":"2010-09","conditions":["Wounds","Wound Healing"],"enrollment":33,"completionDate":"2010-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000007931","NDDF":"002800","UNII":"877376V2XW","INN_ID":"1344","RXNORM":"10968","UMLSCUI":"C0041499","ChEMBL_ID":"CHEMBL577736","KEGG_DRUG":"D06262","DRUGBANK_ID":"DB13503","PUBCHEM_CID":"452550","SNOMEDCT_US":"36661005","MESH_DESCRIPTOR_UI":"D014449"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":348,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"D06AX08","allCodes":["D06AX08","R02AB02","S01AA05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 13","pmid":"41595705","title":"Potential Molecular Targets of the Broad-Range Antimicrobial Peptide Tyrothricin in the Apicomplexan Parasite Toxoplasma gondii.","journal":"Biomedicines"},{"date":"2025","pmid":"40899887","title":"[Treatment of acute tonsillopharyngitis in elderly patients: aspects of complex topical therapy].","journal":"Vestnik otorinolaringologii"},{"date":"2025 Jan 3","pmid":"39471310","title":"Over-the-counter antibiotics compromising aminoglycoside activity.","journal":"The Journal of antimicrobial chemotherapy"},{"date":"2024 Oct 10","pmid":"39451299","title":"An Overview of Microorganisms Immobilized in a Gel Structure for the Production of Precursors, Antibiotics, and Valuable Products.","journal":"Gels (Basel, Switzerland)"},{"date":"2022","pmid":"36404690","title":"[Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx].","journal":"Vestnik otorinolaringologii"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Recombinant protein","firstApprovalDate":"","aiSummary":"Tirotrisin is a protein modality. It is also known by several synonyms, including BACTRATYCIN, COLTIROT, DERMOTRICINE, HYDROTRICINE, MARTRICIN, and NSC-757363.","enrichmentLevel":5,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:49:04.257292+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}