{"id":"tyropanoate","rwe":[],"tags":[{"label":"tyropanoate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V08AC09","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Diagnostic aid","category":"indication"},{"label":"Approved 1960s","category":"decade"},{"label":"Contrast Media","category":"pharmacology"},{"label":"Diagnostic Uses of Chemicals","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=tyropanoate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:03:42.074293+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Tyropanoate","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T01:03:49.136386+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:03:47.760346+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tyropanoate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:03:48.073807+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200899/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:03:48.787547+00:00"}},"allNames":"tyropanoic acid","offLabel":[],"synonyms":["tyropanoic acid","tyropanoate","tyropanoate sodium"],"timeline":[{"date":"1969-10-24","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"approvals":[{"date":"1969-10-24","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Tyropanoic Acid","ecosystem":[{"indication":"Diagnostic aid","otherDrugs":[{"name":"ceruletide","slug":"ceruletide","company":"Pharmacia And Upjohn"},{"name":"iopanoic acid","slug":"iopanoic-acid","company":""},{"name":"iopodic acid","slug":"iopodic-acid","company":"Bracco"},{"name":"sincalide","slug":"sincalide","company":"Bracco"}],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","drugClass":"tyropanoate","explanation":"","oneSentence":"","technicalDetail":"The exact mechanism of action of tyropanoic acid is unknown, but it is believed to involve binding to a specific protein or receptor in the body, which triggers a diagnostic response."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Tyropanoic_acid","title":"Tyropanoic acid","extract":"Tyropanoic acid and its salt sodium tyropanoate are radiocontrast agents used in cholecystography. Trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. This molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones to produce a visible image. After injection it is rapidly excreted into the bile."},"commercial":{"launchDate":"1969","_launchSource":"DrugCentral (FDA 1969-10-24, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2785","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tyropanoate","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Tyropanoic_acid","fields":["history","overview"],"source":"Wikipedia"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T16:10:58.689186","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:03:50.724149+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"iodoxamic 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