{"id":"tylenol-with-codeine","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":{"setId":"160cd55a-a8ed-43f2-baf7-046d3c3b317f","title":"TYLENOL WITH CODEINE (ACETAMINOPHEN AND CODEINE PHOSPHATE) TABLET [A-S MEDICATION SOLUTIONS]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen (paracetamol) works primarily by inhibiting cyclooxygenase enzymes in the central nervous system, reducing prostaglandin production and lowering pain perception and body temperature set point. Codeine is a weak opioid that binds to mu opioid receptors in the brain and spinal cord, providing additional analgesic effects. The combination provides synergistic pain relief for moderate pain that does not respond adequately to acetaminophen alone.","oneSentence":"Acetaminophen reduces fever and mild-to-moderate pain through inhibition of prostaglandin synthesis, while codeine is an opioid agonist that enhances pain relief through central nervous system depression.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:15:09.672Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Pain management in adults and children"}]},"trialDetails":[{"nctId":"NCT07435077","phase":"PHASE4","title":"Examining Analgesic Synergy and Efficacy in Trauma Care","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Opioid Use Disorder","enrollment":282},{"nctId":"NCT02439034","phase":"PHASE2","title":"Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy (KETOCOL-1304)","status":"COMPLETED","sponsor":"Centre Oscar Lambret","startDate":"2015-02","conditions":"Uterine Cervical Cancer, Upper Aerodigestive Tract Neoplasms","enrollment":68},{"nctId":"NCT02858310","phase":"PHASE1, PHASE2","title":"E7 TCR T Cells for Human Papillomavirus-Associated Cancers","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2017-01-27","conditions":"Papillomavirus Infections, Cervical Intraepithelial Neoplasia, Carcinoma In Situ","enrollment":224},{"nctId":"NCT05488847","phase":"PHASE4","title":"Opioid-Free Pain Protocol After Shoulder Arthroplasty","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-25","conditions":"Shoulder Arthropathy, Shoulder Pain","enrollment":83},{"nctId":"NCT07348627","phase":"PHASE3","title":"Opioid-Sparing Joint Replacement","status":"NOT_YET_RECRUITING","sponsor":"Emory University","startDate":"2026-02","conditions":"Pain Management, Opioid Consumption","enrollment":120},{"nctId":"NCT07296770","phase":"PHASE3","title":"An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-05-01","conditions":"Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery","enrollment":126},{"nctId":"NCT06505187","phase":"PHASE2","title":"Celecoxib for ENT Pain Management","status":"RECRUITING","sponsor":"University of Wisconsin, Madison","startDate":"2025-02-28","conditions":"Parotidectomy","enrollment":84},{"nctId":"NCT03823534","phase":"PHASE3","title":"Post-Op Pain Control for Prophylactic Intramedullary Nailing.","status":"RECRUITING","sponsor":"St. Louis University","startDate":"2019-02-20","conditions":"Bone Metastases, Lymphoma, Multiple Myeloma","enrollment":60},{"nctId":"NCT06973785","phase":"PHASE3","title":"Non-Narcotic Pain Control After ACL Reconstruction","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2025-07-15","conditions":"ACL - Anterior Cruciate Ligament Rupture, ACL Injuries","enrollment":30},{"nctId":"NCT04240626","phase":"PHASE4","title":"Multimodal Analgesia Effect on Post Surgical Patient","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of California, Davis","startDate":"2021-01-20","conditions":"Obesity, Morbid, Surgery, Bariatric Surgery Candidate","enrollment":60},{"nctId":"NCT05477875","phase":"PHASE2","title":"Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control","status":"COMPLETED","sponsor":"University of Florida","startDate":"2024-02-01","conditions":"Photorefractive Keratectomy, Myopia, Hyperopia","enrollment":35},{"nctId":"NCT06757140","phase":"PHASE1, PHASE2","title":"Opioid Drug Interaction Study","status":"RECRUITING","sponsor":"Shanna Babalonis, PhD","startDate":"2025-04-01","conditions":"Drug Interactions, Drug Kinetics","enrollment":25},{"nctId":"NCT06916234","phase":"PHASE4","title":"Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain","status":"COMPLETED","sponsor":"ibrahim doğru","startDate":"2023-01-10","conditions":"Acute Dental Pain","enrollment":100},{"nctId":"NCT06340932","phase":"","title":"Impact of Opioid Avoidance Protocol for ACL Reconstruction","status":"COMPLETED","sponsor":"Matthew Varacallo","startDate":"2024-04-27","conditions":"ACL Tear, Post Operative Pain","enrollment":32},{"nctId":"NCT04761302","phase":"PHASE4","title":"Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures","status":"COMPLETED","sponsor":"University of Puerto Rico","startDate":"2021-04-18","conditions":"Femur Fracture, Tibial Fractures","enrollment":167},{"nctId":"NCT03987022","phase":"PHASE4","title":"ICE-T Pain Regimen for Total Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"MetroHealth Medical Center","startDate":"2019-08-01","conditions":"Opioid Substitution Treatment","enrollment":66},{"nctId":"NCT05463367","phase":"PHASE2","title":"Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure","status":"ACTIVE_NOT_RECRUITING","sponsor":"Northwestern University","startDate":"2021-01-01","conditions":"Opioid Use, Opioid Dependence, Opioid-use Disorder","enrollment":60},{"nctId":"NCT03859024","phase":"PHASE4","title":"Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2019-03-22","conditions":"Pain, Postoperative, Urethral Stricture","enrollment":48},{"nctId":"NCT04791761","phase":"PHASE1, PHASE2","title":"Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy","status":"TERMINATED","sponsor":"David Chi, MD","startDate":"2021-04-13","conditions":"Adenotonsillectomy, Post-operative Analgesia, Opioid Use","enrollment":73},{"nctId":"NCT04015908","phase":"PHASE4","title":"A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery","status":"COMPLETED","sponsor":"University of Utah","startDate":"2019-08-01","conditions":"Opioid Use","enrollment":100},{"nctId":"NCT06415331","phase":"NA","title":"Effectiveness of Conventional Therapy Plus Pulsed-Radiofrequency for Herniated Nucleus Pulposus","status":"COMPLETED","sponsor":"Dr. Syaiful Anwar Hospital, Malang","startDate":"2023-02-02","conditions":"Herniated Nucleus Pulposus, Pain","enrollment":60},{"nctId":"NCT04642404","phase":"PHASE1, PHASE2","title":"CBD for Dental Pain","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2021-03-01","conditions":"Odontalgia, Toothache","enrollment":64},{"nctId":"NCT02929589","phase":"PHASE3","title":"Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy","status":"TERMINATED","sponsor":"Mike O'Callaghan Military Hospital","startDate":"2018-07-05","conditions":"Pain, Hernia","enrollment":18},{"nctId":"NCT04122443","phase":"PHASE4","title":"Acetaminophen (APAP) +/- Oxycodone","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2019-12-01","conditions":"Musculoskeletal Pain","enrollment":393},{"nctId":"NCT03415555","phase":"PHASE4","title":"Postoperative Analgesia After Minithoracotomy","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2018-02-07","conditions":"Postoperative Pain, Mitral Valve Disease","enrollment":19},{"nctId":"NCT06095258","phase":"PHASE2","title":"A Practical RCT of TCM in the Treatment of LCOVID and Analysis of Syndrome Types and Medication Characteristics.","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2023-12-01","conditions":"Long COVID","enrollment":162},{"nctId":"NCT04149964","phase":"PHASE4","title":"Postoperative Pain Control in Septum and Sinus Surgery","status":"COMPLETED","sponsor":"Corewell Health East","startDate":"2019-11-27","conditions":"Post-operative Pain, Sinus Surgery","enrollment":65},{"nctId":"NCT04246697","phase":"PHASE4","title":"Multimodal Pain Study in Free Flap Patients","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2019-11-01","conditions":"Head and Neck Cancer, Analgesia","enrollment":30},{"nctId":"NCT04976387","phase":"PHASE3","title":"Post Operative Analgesia and Patient Satisfaction","status":"COMPLETED","sponsor":"Loma Linda University","startDate":"2021-07-02","conditions":"Postoperative Pain, Patient Satisfaction, Analgesia","enrollment":150},{"nctId":"NCT05974423","phase":"PHASE4","title":"Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair","status":"UNKNOWN","sponsor":"The Cooper Health System","startDate":"2022-12-16","conditions":"Postoperative Pain, Acute, Opioid Use, Labral Tear, Glenoid","enrollment":60},{"nctId":"NCT04429022","phase":"PHASE3","title":"Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"State University of New York at Buffalo","startDate":"2020-11-24","conditions":"Pain, Postoperative","enrollment":68},{"nctId":"NCT02358850","phase":"PHASE4","title":"Post-tonsillectomy Pain Control in Adults","status":"TERMINATED","sponsor":"University of Nebraska","startDate":"2016-01","conditions":"Pain, Postoperative, Postoperative Nausea and Vomiting, Postoperative Hemorrhage","enrollment":27},{"nctId":"NCT05229965","phase":"PHASE3","title":"Paracetamol Vs Caffeine Vs Codeine in the Management of Post Traumatic Pain in Emergencies","status":"COMPLETED","sponsor":"University of Monastir","startDate":"2022-11-01","conditions":"Acute Pain Due to Trauma","enrollment":1500},{"nctId":"NCT04194528","phase":"NA","title":"S1916 Digital Medicine Program for Pain Control in Cancer Patients","status":"TERMINATED","sponsor":"SWOG Cancer Research Network","startDate":"2020-01-22","conditions":"Metastatic Cancer","enrollment":2},{"nctId":"NCT03055507","phase":"PHASE2, PHASE3","title":"Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis","status":"COMPLETED","sponsor":"University of Washington","startDate":"2017-04-01","conditions":"Chronic Rhinosinusitis (Diagnosis)","enrollment":42},{"nctId":"NCT04612920","phase":"EARLY_PHASE1","title":"Towards Enhanced Recovery After Cesarean","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2020-12-12","conditions":"Cesarean Section Complications","enrollment":33},{"nctId":"NCT02153177","phase":"PHASE4","title":"The Effect of NSAIDs After a Rotator Cuff Repair Surgery.","status":"WITHDRAWN","sponsor":"University of Chicago","startDate":"2015-01","conditions":"Rotator Cuff Tear","enrollment":""},{"nctId":"NCT04874675","phase":"NA","title":"An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery","status":"SUSPENDED","sponsor":"University of Zimbabwe","startDate":"2023-03","conditions":"Impacted Third Molar Tooth, PAIN","enrollment":78},{"nctId":"NCT03879408","phase":"PHASE2","title":"Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division","startDate":"2019-05-28","conditions":"Pain","enrollment":290},{"nctId":"NCT03105518","phase":"PHASE4","title":"Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction","status":"UNKNOWN","sponsor":"Brigham and Women's Hospital","startDate":"2011-03-01","conditions":"Oocyte Retrieval, Postoperative Pain","enrollment":100},{"nctId":"NCT03471442","phase":"NA","title":"Erector Spinae Plane Block Versus Paravertebral Block","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2018-05-29","conditions":"Breast Cancer, Pain, Postoperative, Anesthesia, Local","enrollment":48},{"nctId":"NCT02845271","phase":"PHASE2","title":"Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Genzyme, a Sanofi Company","startDate":"2016-07-21","conditions":"Osteoarthritis","enrollment":104},{"nctId":"NCT02487108","phase":"PHASE3","title":"Study to Evaluate the Analgesic Efficacy and Safety of Hydrocodone Bitartrate/Acetaminophen Immediate-Release Tablets in Participants With Moderate to Severe Pain Following Bunionectomy","status":"COMPLETED","sponsor":"Teva Branded Pharmaceutical Products R&D, Inc.","startDate":"2015-08-11","conditions":"Pain","enrollment":569},{"nctId":"NCT02932579","phase":"PHASE4","title":"Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes","status":"TERMINATED","sponsor":"University of Rochester","startDate":"2017-07-01","conditions":"Pain","enrollment":59},{"nctId":"NCT03088826","phase":"PHASE2","title":"Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)","status":"COMPLETED","sponsor":"Antonios Likourezos","startDate":"2017-08-18","conditions":"Pain Management","enrollment":80},{"nctId":"NCT00694369","phase":"PHASE3","title":"A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2008-06","conditions":"Postoperative Dental Pain","enrollment":588},{"nctId":"NCT03173456","phase":"PHASE2","title":"Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)","status":"COMPLETED","sponsor":"Albert Einstein College of Medicine","startDate":"2017-11-28","conditions":"Musculoskeletal Pain","enrollment":600},{"nctId":"NCT00394550","phase":"NA","title":"Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty","status":"TERMINATED","sponsor":"Indiana University School of Medicine","startDate":"2002-01","conditions":"Sleep Apnea, Obstructive, Respiration Disorders","enrollment":160},{"nctId":"NCT05161221","phase":"PHASE3","title":"Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2021-12-06","conditions":"Pain, Postoperative, ACL","enrollment":154},{"nctId":"NCT05154682","phase":"PHASE3","title":"Pain Management After Surgery","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2021-11-30","conditions":"Pain, Postoperative","enrollment":200},{"nctId":"NCT03618823","phase":"PHASE1, PHASE2","title":"Non-opioids for Analgesia After Adenotonsillectomy in Children","status":"TERMINATED","sponsor":"David Chi, MD","startDate":"2018-10-25","conditions":"Adenotonsillectomy, Post-operative Analgesia, Opioid Use","enrollment":268},{"nctId":"NCT04726878","phase":"PHASE4","title":"ESP in Breast Surgery Due to Cancer","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2021-02-01","conditions":"Breast Cancer, Pain, Acute, Anesthesia, Local","enrollment":75},{"nctId":"NCT03435692","phase":"NA","title":"Post Operative Pain Control After Pediatric Hip Surgery","status":"TERMINATED","sponsor":"Seattle Children's Hospital","startDate":"2011-07-15","conditions":"Hip Surgery, Post Operative Pain Control","enrollment":42},{"nctId":"NCT04399122","phase":"PHASE4","title":"Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone","status":"COMPLETED","sponsor":"59th Medical Wing","startDate":"2017-03-21","conditions":"Post-operative Pain Control","enrollment":200},{"nctId":"NCT03586934","phase":"PHASE3","title":"Multimodal Analgesia in Shoulder Arthroplasty","status":"WITHDRAWN","sponsor":"Rush University Medical Center","startDate":"2018-06-01","conditions":"Shoulder Pain, Opioid Use","enrollment":""},{"nctId":"NCT03783702","phase":"PHASE4","title":"Pain Control Following Sinus Surgery","status":"COMPLETED","sponsor":"Stanford University","startDate":"2019-04-04","conditions":"Sinusitis, Opioid Use, Opioid Abuse","enrollment":118},{"nctId":"NCT05024825","phase":"PHASE4","title":"Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy","status":"TERMINATED","sponsor":"Albany Medical College","startDate":"2017-08-04","conditions":"Pain, Postoperative","enrollment":17},{"nctId":"NCT03599089","phase":"PHASE2","title":"Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients","status":"COMPLETED","sponsor":"Concentric Analgesics","startDate":"2018-07-09","conditions":"Post-surgical Pain","enrollment":147},{"nctId":"NCT04202406","phase":"NA","title":"Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-01-09","conditions":"Symptomatic Irreversible Pulpitis","enrollment":69},{"nctId":"NCT03469310","phase":"PHASE4","title":"Minimizing Narcotic Analgesics After Endocrine Surgery","status":"COMPLETED","sponsor":"Minerva A Romero Arenas","startDate":"2018-03-09","conditions":"Thyroid Cancer, Thyroid Nodule, Thyroid Neoplasms","enrollment":126},{"nctId":"NCT04066426","phase":"PHASE4","title":"Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2018-03-01","conditions":"Temporomandibular Disorder","enrollment":200},{"nctId":"NCT04730297","phase":"PHASE4","title":"Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery","status":"COMPLETED","sponsor":"University of Roma La Sapienza","startDate":"2018-01-01","conditions":"To Control Pain After Third Molar Surgery","enrollment":120},{"nctId":"NCT03011905","phase":"PHASE3","title":"Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2017-01","conditions":"Brachial Plexus Block, Pain, Postoperative","enrollment":53},{"nctId":"NCT04259333","phase":"PHASE4","title":"Celecoxib vs. Acetaminophen/Codeine/Caffeine for Post-operative Analgesia in Rhinoplasty.","status":"UNKNOWN","sponsor":"Blake Raggio","startDate":"2020-03-01","conditions":"Pain, Postoperative, Surgery--Complications, Opioid Analgesic Adverse Reaction","enrollment":60},{"nctId":"NCT04018768","phase":"","title":"Multimodal Analgesia With NSAID vs. Narcotics Alone After Shoulder Instability Surgery","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2017-12-01","conditions":"Shoulder Pain","enrollment":80},{"nctId":"NCT03080493","phase":"PHASE4","title":"Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2017-03-20","conditions":"Abortion, Induced, Cervical Preparation, Pain","enrollment":121},{"nctId":"NCT01335646","phase":"NA","title":"Surgery Versus Standardized Non-operative Care for the Treatment of Lumbar Disc Herniations: A Canadian Trial","status":"COMPLETED","sponsor":"The London Spine Centre","startDate":"2010-03-21","conditions":"Lumbar Spine Disc Herniation, Lumbar Radiculopathy","enrollment":128},{"nctId":"NCT02934191","phase":"PHASE2","title":"Celecoxib After Tonsillectomy","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2016-06","conditions":"Tonsillectomy","enrollment":172},{"nctId":"NCT03640247","phase":"PHASE1","title":"Pain Medications Following Thyroidectomy and Parathyroidectomy","status":"COMPLETED","sponsor":"MetroHealth Medical Center","startDate":"2018-11-15","conditions":"Thyroid Disease, Parathyroid Diseases","enrollment":126},{"nctId":"NCT03478423","phase":"NA","title":"Opioid Analgesics for Acute Fracture Pain in Adults Discharged From the ED","status":"TERMINATED","sponsor":"Mount Sinai Hospital, Canada","startDate":"2018-02-05","conditions":"Acute Pain","enrollment":5},{"nctId":"NCT03111186","phase":"PHASE2","title":"Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2017-04-24","conditions":"Carpal Tunnel Syndrome, Dupuytren Contracture, Trigger Digit","enrollment":40},{"nctId":"NCT00386243","phase":"NA","title":"Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2007-12","conditions":"Low Back Pain, Pain, Pain, Intractable","enrollment":242},{"nctId":"NCT04003350","phase":"NA","title":"The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Rothman Institute Orthopaedics","startDate":"2017-12-21","conditions":"Osteo Arthritis Knee","enrollment":216},{"nctId":"NCT03996564","phase":"NA","title":"Battlefield Acupuncture for Acute/Subacute Back Pain in the Emergency Department","status":"COMPLETED","sponsor":"San Antonio Military Medical Center","startDate":"2016-02-22","conditions":"Low Back Pain, Mechanical","enrollment":26},{"nctId":"NCT03592485","phase":"PHASE4","title":"ESP vs ESP With PECS","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2018-06-28","conditions":"Postoperative Pain, Mitral Valve Disease","enrollment":33},{"nctId":"NCT02647788","phase":"PHASE4","title":"Acetaminophen/Codeine vs Acetaminophen/Ibuprofen for Pain Control and Patient Satisfaction After Hand Surgery","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2015-12","conditions":"Pain, Postoperative","enrollment":144},{"nctId":"NCT02519023","phase":"PHASE4","title":"TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2016-07","conditions":"Acute Pain","enrollment":87},{"nctId":"NCT00281684","phase":"PHASE2","title":"SB-705498 Dental Pain Study After Tooth Extraction","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-12-07","conditions":"Toothache","enrollment":145},{"nctId":"NCT03549611","phase":"PHASE4","title":"Pre-induction Analgesia: Multimodel Regimen vs Aceteminophen for Post Ureteroscopy Pain","status":"WITHDRAWN","sponsor":"Kevin J Flynn MD","startDate":"2018-08-01","conditions":"Kidney Calculi, Pain, Postoperative","enrollment":""},{"nctId":"NCT03619785","phase":"PHASE4","title":"US-guided SAPB for Rib Fractures in the ED","status":"UNKNOWN","sponsor":"Andrew A Herring","startDate":"2018-11-06","conditions":"Rib Fractures, Rib Fracture Multiple","enrollment":70},{"nctId":"NCT01003639","phase":"PHASE2, PHASE3","title":"Idiopathic Intracranial Hypertension Treatment Trial","status":"COMPLETED","sponsor":"St. Luke's-Roosevelt Hospital Center","startDate":"2010-01","conditions":"Idiopathic Intracranial Hypertension","enrollment":165},{"nctId":"NCT03770806","phase":"NA","title":"Factors Affecting the Speed of Recovery After ACL Reconstruction","status":"COMPLETED","sponsor":"University of Washington","startDate":"2017-03-24","conditions":"Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture","enrollment":48},{"nctId":"NCT01229449","phase":"PHASE3","title":"Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study","status":"COMPLETED","sponsor":"Reckitt Benckiser LLC","startDate":"2009-01","conditions":"Post-operative Pain","enrollment":678},{"nctId":"NCT02094807","phase":"NA","title":"Pain as Indication for Operative Treatment of Traumatic Rib Fractures","status":"WITHDRAWN","sponsor":"Sahlgrenska University Hospital","startDate":"2014-04","conditions":"Trauma, Rib Fractures, Surgery","enrollment":""},{"nctId":"NCT02862691","phase":"PHASE2","title":"Percocet vs. Bupivicaine for Toothaches in the ED","status":"TERMINATED","sponsor":"Stony Brook University","startDate":"2016-08-01","conditions":"Toothache","enrollment":2},{"nctId":"NCT02455518","phase":"PHASE4","title":"Comparative Efficacy of 4 Oral Analgesics","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2015-07","conditions":"Pain","enrollment":416},{"nctId":"NCT02295124","phase":"PHASE4","title":"Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2012-08","conditions":"Nausea","enrollment":200},{"nctId":"NCT03280095","phase":"PHASE1","title":"Bioequivalence Study of Co-codamol 15mg/500mg Capsules vs Co-codamol 30mg/500mg Tablets in Healthy Subjects","status":"COMPLETED","sponsor":"Galen Limited","startDate":"2014-09-23","conditions":"Healthy","enrollment":50},{"nctId":"NCT02540512","phase":"EARLY_PHASE1","title":"Acupuncture for Pain in the Emergency Department","status":"WITHDRAWN","sponsor":"Loma Linda University","startDate":"2017-07-27","conditions":"Musculoskeletal Pain, Pain","enrollment":""},{"nctId":"NCT00314340","phase":"PHASE4","title":"A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2005-11","conditions":"Chronic Pain","enrollment":12},{"nctId":"NCT02440399","phase":"NA","title":"To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine","status":"COMPLETED","sponsor":"HaEmek Medical Center, Israel","startDate":"2015-07","conditions":"Post Cesarean Pain Management","enrollment":200},{"nctId":"NCT02032927","phase":"PHASE4","title":"Treatment of Chronic Pain From Osteoarthritis","status":"WITHDRAWN","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2013-06","conditions":"Chronic Pain","enrollment":""},{"nctId":"NCT02958566","phase":"PHASE4","title":"Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Illinois College of Medicine at Peoria","startDate":"2017-01","conditions":"Colon Cancer, Colon Diverticulosis, Colonic Neoplasms","enrollment":80},{"nctId":"NCT01588158","phase":"PHASE4","title":"Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery","status":"TERMINATED","sponsor":"Massachusetts General Hospital","startDate":"2012-07","conditions":"Carpal Tunnel Syndrome","enrollment":7},{"nctId":"NCT02236130","phase":"NA","title":"Peripheral Nerve Blocks in Pediatric Orthopedic Patients","status":"TERMINATED","sponsor":"University of Mississippi Medical Center","startDate":"2014-06","conditions":"Pediatric Extremity Fracture, Pediatric Extremity Soft Tissue Injury","enrollment":49},{"nctId":"NCT03049878","phase":"PHASE4","title":"Efficacy of Preoperative Administration of Paracetamol-codeine on Pain Following Impacted Mandibular Third Molar Surgery","status":"COMPLETED","sponsor":"University of Roma La Sapienza","startDate":"2013-02-21","conditions":"To Control Pain After Third Molar Surgery","enrollment":32},{"nctId":"NCT00390260","phase":"PHASE3","title":"Effect of Rofecoxib and a Narcotic Analgesic to Treat Pain Following Arthroscopic Surgery (0966-179)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2002-02","conditions":"Pain, Postoperative Arthroscopy","enrollment":420},{"nctId":"NCT01982799","phase":"NA","title":"Local Anesthesia and Analgesics in Endodontic Pain","status":"WITHDRAWN","sponsor":"University of Minnesota","startDate":"2014-02","conditions":"Odontalgia","enrollment":""},{"nctId":"NCT02750696","phase":"NA","title":"Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess","status":"COMPLETED","sponsor":"Federal University of Rio Grande do Sul","startDate":"2013-04","conditions":"Periapical Abscess","enrollment":27},{"nctId":"NCT00921700","phase":"PHASE4","title":"Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination","status":"COMPLETED","sponsor":"Ullevaal University Hospital","startDate":"2009-06","conditions":"Pain, Postoperative","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tylenol with codeine","genericName":"Tylenol with codeine","companyName":"National Center for Complementary and Integrative Health (NCCIH)","companyId":"national-center-for-complementary-and-integrative-health-nccih","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acetaminophen reduces fever and mild-to-moderate pain through inhibition of prostaglandin synthesis, while codeine is an opioid agonist that enhances pain relief through central nervous system depression. Used for Mild to moderate pain, Pain management in adults and children.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}