{"id":"two-vaccine-injections-dtp-pertussis-hib","safety":{"commonSideEffects":[{"rate":"10–50%","effect":"Injection site pain, redness, or swelling"},{"rate":"5–15%","effect":"Fever"},{"rate":"5–10%","effect":"Irritability or fussiness"},{"rate":"5–10%","effect":"Drowsiness"},{"rate":"5–10%","effect":"Loss of appetite"}]},"_chembl":{"chemblId":"CHEMBL2109219","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains inactivated toxins from diphtheria and tetanus bacteria, acellular pertussis antigens, and Hib polysaccharide conjugate. Upon injection, these antigens trigger both humoral (antibody) and cell-mediated immune responses, priming the immune system to recognize and neutralize these pathogens upon future exposure. The two-injection series provides primary immunization against these four serious bacterial infections.","oneSentence":"This combination vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis (whooping cough), and Haemophilus influenzae type b (Hib) bacteria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:42:03.496Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of diphtheria"},{"name":"Prevention of tetanus"},{"name":"Prevention of pertussis (whooping cough)"},{"name":"Prevention of Haemophilus influenzae type b infection"}]},"trialDetails":[{"nctId":"NCT02179996","phase":"PHASE4","title":"Diphtheria, Tetanus, Poliomyelitis -Pertussis-Hib Immunisation in Preterm-born Neonates","status":"UNKNOWN","sponsor":"Central Hospital, Nancy, France","startDate":"2014-01","conditions":"Hib Immunisation in Very Preterm-born Infants, Pertussis Immunisation in Very Preterm-born Infants","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Two vaccine injections DTP-pertussis-Hib","genericName":"Two vaccine injections DTP-pertussis-Hib","companyName":"Central Hospital, Nancy, France","companyId":"central-hospital-nancy-france","modality":"Biologic","firstApprovalDate":"","aiSummary":"This combination vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis (whooping cough), and Haemophilus influenzae type b (Hib) bacteria. Used for Prevention of diphtheria, Prevention of tetanus, Prevention of pertussis (whooping cough).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}