{"id":"twinrix-junior","safety":{"commonSideEffects":[{"rate":"20-40","effect":"Injection site pain/soreness"},{"rate":"5-15","effect":"Fever"},{"rate":"5-10","effect":"Fatigue"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"The vaccine contains inactivated hepatitis A virus and recombinant hepatitis B surface antigen, which trigger both humoral and cellular immune responses. This results in the production of protective antibodies (anti-HAV and anti-HBs) that prevent infection by these two hepatitis viruses. The junior formulation contains lower antigen doses than the adult version, appropriate for pediatric immunization.","oneSentence":"Twinrix Junior is a combined vaccine that stimulates the immune system to produce antibodies against hepatitis A and hepatitis B viruses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:51:33.530Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of hepatitis A and hepatitis B in infants and children (typically ages 12 months to 18 years)"}]},"trialDetails":[{"nctId":"NCT00875485","phase":"PHASE4","title":"Evaluation of Antibody Persistence & Immune Memory in Subjects Vaccinated During Adolescence With Twinrix™","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-05-01","conditions":"Hepatitis B, Hepatitis A","enrollment":210},{"nctId":"NCT00197184","phase":"PHASE3","title":"Long Term Follow-up Study at Years 2, 3, 4 and 5 Where 2 Dosing Schedules of the Combined Hepatitis A and B Vaccine Were Compared","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2003-11-01","conditions":"Hepatitis B, Hepatitis A","enrollment":276},{"nctId":"NCT00465816","phase":"PHASE3","title":"Primary Study to Demonstrate Non-inferiority and Immunogenicity of GSK Biologicals' Meningococcal Vaccine 134612","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-04-11","conditions":"Infections, Meningococcal","enrollment":611},{"nctId":"NCT00197119","phase":"PHASE3","title":"Long-Term Follow-Up Studies at Year 6, 7, 8, 9, 10: 2 Formulations of Combined Hepatitis A/B Vaccine Compared in Subjects Aged 12-15 Years","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2004-05","conditions":"Hepatitis B, Hepatitis A","enrollment":244}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Combined hepatitis A and B vaccine"],"phase":"phase_3","status":"active","brandName":"Twinrix™ Junior","genericName":"Twinrix™ Junior","companyName":"GlaxoSmithKline","companyId":"glaxosmithkline","modality":"Biologic","firstApprovalDate":"","aiSummary":"Twinrix Junior is a combined vaccine that stimulates the immune system to produce antibodies against hepatitis A and hepatitis B viruses. Used for Prevention of hepatitis A and hepatitis B in infants and children (typically ages 12 months to 18 years).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}