{"id":"trypsin-chymotrypsin","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Local irritation at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination of serine proteases works by digesting denatured proteins, fibrin deposits, and inflammatory exudates at sites of injury or inflammation. By clearing proteinaceous debris and reducing local inflammation, these enzymes promote tissue repair and can enhance the bioavailability of co-administered medications. The enzymes are typically used topically or systemically for their anti-inflammatory and proteolytic properties.","oneSentence":"Trypsin and chymotrypsin are proteolytic enzymes that break down proteins and fibrin to reduce inflammation, improve tissue healing, and enhance absorption of other drugs.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:35:46.811Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammation and swelling reduction"},{"name":"Wound healing and tissue repair"},{"name":"Digestive enzyme supplementation"}]},"trialDetails":[{"nctId":"NCT05659147","phase":"PHASE4","title":"Imaging Biomarkers of Pancreatic Function and Disease","status":"ENROLLING_BY_INVITATION","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2023-01-18","conditions":"Pancreatitis, Diabetes Mellitus","enrollment":195},{"nctId":"NCT07269171","phase":"NA","title":"The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery","status":"NOT_YET_RECRUITING","sponsor":"Saglik Bilimleri Universitesi","startDate":"2025-12-01","conditions":"Oral Health Care","enrollment":15},{"nctId":"NCT07088042","phase":"PHASE4","title":"Assessment of Different Medications in Modifying the Efficacy of Anesthesia in Mandibular Molars With Acute Irreversible Pulpitis","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-09-15","conditions":"Pulpitis - Irreversible","enrollment":60},{"nctId":"NCT06713733","phase":"NA","title":"Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery","status":"RECRUITING","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2024-09-25","conditions":"Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery","enrollment":50},{"nctId":"NCT06562816","phase":"PHASE4","title":"Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain","status":"RECRUITING","sponsor":"Dow University of Health Sciences","startDate":"2024-08-16","conditions":"Effect of Drug","enrollment":100},{"nctId":"NCT06671743","phase":"PHASE3","title":"Premedication on Post-endodontic Pain","status":"RECRUITING","sponsor":"Gulf Medical University","startDate":"2024-09-01","conditions":"Premedication","enrollment":48},{"nctId":"NCT05479747","phase":"PHASE4","title":"Efficacy of Trypsin-Chymotrypsin On Post-operative Pain After Single Visit Root Canal Treatment","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-06-01","conditions":"Effect of Drug","enrollment":60},{"nctId":"NCT04362384","phase":"PHASE3","title":"Topical Vitamin E Ovules for the Treatment of Hemorrhoids","status":"UNKNOWN","sponsor":"Hospital General Universitario Elche","startDate":"2020-05-01","conditions":"Bleeding Anal, Pain, Stings","enrollment":120},{"nctId":"NCT03346447","phase":"","title":"Effect of Baby Wipe Solutions on Fecal Enzyme-induced Irritation","status":"COMPLETED","sponsor":"Kimberly-Clark Corporation","startDate":"2017-10-09","conditions":"Skin Health","enrollment":23},{"nctId":"NCT02979210","phase":"NA","title":"Infant Fecal Insult Study","status":"COMPLETED","sponsor":"Kimberly-Clark Corporation","startDate":"2016-11","conditions":"Dermatitis","enrollment":24},{"nctId":"NCT01489514","phase":"","title":"Evaluation of Allergenicity of Hypoallergenic Peanut Product in Peanut Allergic Subjects","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2011-12","conditions":"Peanut Allergy","enrollment":22},{"nctId":"NCT00014339","phase":"PHASE3","title":"Chemotherapy With or Without Wobe-Mugos E in Treating Patients With Stage II or Stage III Multiple Myeloma","status":"UNKNOWN","sponsor":"Medsearch","startDate":"2000-03","conditions":"Multiple Myeloma and Plasma Cell Neoplasm","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"TREMOR"},{"count":1,"reaction":"URINARY TRACT INFECTION"}],"_approvalHistory":[],"publicationCount":1553,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chymoral Forte"],"phase":"marketed","status":"active","brandName":"Trypsin-Chymotrypsin","genericName":"Trypsin-Chymotrypsin","companyName":"Dow University of Health Sciences","companyId":"dow-university-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trypsin and chymotrypsin are proteolytic enzymes that break down proteins and fibrin to reduce inflammation, improve tissue healing, and enhance absorption of other drugs. Used for Inflammation and swelling reduction, Wound healing and tissue repair, Digestive enzyme supplementation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}