{"id":"tryparsamide","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tryparsone","offLabel":[],"synonyms":["tryparsamide","triparsamide","tryparsamid","tryparsone","tryponarsyl"],"timeline":[],"approvals":[],"brandName":"Tryparsone","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Think of it like a key that fits into a lock. The lock is the enzyme dihydrofolate reductase, and the key is Tryparsone. When Tryparsone fits into the lock, it prevents the enzyme from working properly, which ultimately kills the parasite.","oneSentence":"Tryparsone works by inhibiting the enzyme dihydrofolate reductase, which is essential for the survival of the trypanosome parasite.","technicalDetail":"Tryptarsone acts as a competitive inhibitor of dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate, which is necessary for the synthesis of purines and ultimately DNA and RNA."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3636","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tryparsamide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:10:21.652393","biosimilars":[],"competitors":[],"genericName":"tryparsamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002963","UNII":"4NN21HAX16","CHEBI":"CHEBI:135130","INN_ID":"435","UMLSCUI":"C0041235","PUBCHEM_CID":"23665572","SNOMEDCT_US":"23969007","MESH_SUPPLEMENTAL_RECORD_UI":"C073345"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Tryparsone is a small molecule. It is used to treat African trypanosomiasis, also known as sleeping sickness, according to ClinicalTrials.gov.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}