{"id":"troxipide","rwe":[{"pmid":"41580852","year":"2026","title":"Troxipide nanosuspensions prevent indomethacin‑induced gastrointestinal lesions in adjuvant-induced arthritis rats.","finding":"","journal":"Journal of pharmaceutical health care and sciences","studyType":"Clinical Study"},{"pmid":"38024531","year":"2023","title":"Therapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters.","finding":"","journal":"Drug design, development and therapy","studyType":"Clinical Study"},{"pmid":"34438012","year":"2021","title":"Cytoprotective agent troxipide-cyanine dye conjugate with cytotoxic and antiproliferative activity in patient-derived glioblastoma cell lines.","finding":"","journal":"Bioorganic & medicinal chemistry letters","studyType":"Clinical Study"},{"pmid":"34079016","year":"2021","title":"Metabolomics analysis of the soapberry (Sapindus mukorossi Gaertn.) pericarp during fruit development and ripening based on UHPLC-HRMS.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"32788674","year":"2020","title":"Metabolites profiling and pharmacokinetics of troxipide and its pharmacodynamics in rats with gastric ulcer.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"}],"tags":[{"label":"troxipide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A02BX11","category":"atc"},{"label":"Active","category":"status"},{"label":"Gastric ulcer","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"aplace","offLabel":[],"synonyms":["aplace","troxipide","KU-54"],"timeline":[],"approvals":[],"brandName":"Aplace","ecosystem":[{"indication":"Gastric ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"famotidine","slug":"famotidine","company":"Valeant Pharms North"},{"name":"lansoprazole","slug":"lansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"troxipide","explanation":"Think of it like a valve that controls the flow of acid into the stomach. Troxipide helps to close this valve, reducing the amount of acid produced and allowing the stomach to heal. This can help to treat gastric ulcers and other conditions related to excess stomach acid.","oneSentence":"Troxipide works by inhibiting the enzyme H+/K+ ATPase, which is involved in stomach acid production.","technicalDetail":"Troxipide acts as a selective inhibitor of the H+/K+ ATPase enzyme, specifically targeting the gastric proton pump to reduce gastric acid secretion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2779","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TROXIPIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:05:17.797396","biosimilars":[],"competitors":[{"drugName":"sucralfate","drugSlug":"sucralfate","fdaApproval":"1981-10-30","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bismuth subcitrate","drugSlug":"bismuth-subcitrate","fdaApproval":"2006-09-28","relationship":"same-class"}],"genericName":"troxipide","indications":{"approved":[{"name":"Gastric ulcer","source":"DrugCentral","snomedId":397825006,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sucralfate","brandName":"sucralfate","genericName":"sucralfate","approvalYear":"1981","relationship":"same-class"},{"drugId":"bismuth-subcitrate","brandName":"bismuth subcitrate","genericName":"bismuth subcitrate","approvalYear":"2006","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"W6QJX1Q00Z","CHEBI":"CHEBI:32271","INN_ID":"5461","UMLSCUI":"C0147037","ChEMBL_ID":"CHEMBL1566956","KEGG_DRUG":"D01306","DRUGBANK_ID":"DB13419","PUBCHEM_CID":"5597","MESH_SUPPLEMENTAL_RECORD_UI":"C028936"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"A02BX11","allCodes":["A02BX11"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 24","pmid":"41580852","title":"Troxipide nanosuspensions prevent indomethacin‑induced gastrointestinal lesions in adjuvant-induced arthritis rats.","journal":"Journal of pharmaceutical health care and sciences"},{"date":"2023","pmid":"38024531","title":"Therapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters.","journal":"Drug design, development and therapy"},{"date":"2021 Oct 15","pmid":"34438012","title":"Cytoprotective agent troxipide-cyanine dye conjugate with cytotoxic and antiproliferative activity in patient-derived glioblastoma cell lines.","journal":"Bioorganic & medicinal chemistry letters"},{"date":"2021 Jun 2","pmid":"34079016","title":"Metabolomics analysis of the soapberry (Sapindus mukorossi Gaertn.) pericarp during fruit development and ripening based on UHPLC-HRMS.","journal":"Scientific reports"},{"date":"2020 Aug 12","pmid":"32788674","title":"Metabolites profiling and pharmacokinetics of troxipide and its pharmacodynamics in rats with gastric ulcer.","journal":"Scientific reports"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aplace is a small molecule modality. It is also known by the synonyms TROXIPIDA, TROXIPIDE, and TROXIPIDE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}