{"id":"trolnitrate","rwe":[{"pmid":"5927953","year":"1966","title":"Protection of rats from isoproterenol induced myocardial necrosis by trolnitrate phosphate (Metamine).","finding":"","journal":"Experientia","studyType":"Clinical Study"},{"pmid":"4284102","year":"1965","title":"Comparative studies on the mechanism of antianginal action of trolnitrate phosphate and nitroglycerin in animals.","finding":"","journal":"The Journal of new drugs","studyType":"Clinical Study"}],"tags":[{"label":"Vasodilators Organic Nitrates","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01DA09","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"contraindications":["Achalasia of esophagus","Acidosis","Acute abdominal pain","Acute cerebrovascular insufficiency","Acute disease of cardiovascular system","Acute erosive gastritis","Acute exacerbation of asthma","Acute hepatitis","Acute nephropathy","Acute pancreatitis","Aggressive behavior","Agoraphobia","Alcohol intoxication","Alcohol withdrawal delirium","Alcohol withdrawal syndrome","Alcoholism","Aluminum intoxication","Anemia","Anemia due to enzyme deficiency","Angina pectoris","Angle-closure glaucoma","Anorexia nervosa","Arterial thrombosis","Arteriosclerotic vascular disease","Asthenia","Ataxia","Autoimmune disease","Benign intracranial hypertension","Benign prostatic hyperplasia","Benzodiazepine Toxicity","Bipolar disorder","Bladder outflow obstruction","Blood coagulation disorder","Body fluid retention","Bone marrow depression","Bradycardia","Breastfeeding (mother)","Cardiac Decompensation","Cardiomyopathy","Cardiovascular event risk","Central nervous system depression","Cerebral trauma","Cerebrovascular accident","Chronic diarrhea","Chronic disease of respiratory system","Chronic heart failure","Chronic idiopathic constipation","Chronic myocardial ischemia","Chronic obstructive lung disease","Chronic renal failure syndrome","Cirrhosis of liver","Coma","Complete atrioventricular block","Conduction disorder of the heart","Congenital long QT syndrome","Congenital myotonia, autosomal dominant form","Constipation","Cor pulmonale","Coronary arteriosclerosis","Decompensated cardiac failure","Decreased respiratory function","Dehydration","Delirium","Dependent drug abuse","Depressive disorder","Diabetes mellitus","Diarrhea","Disease of liver","Disorder of biliary tract","Disorder of cardiovascular system","Disorder of coronary artery","Disorder of gallbladder","Drug AND/OR toxin-induced diarrhea","Drug withdrawal","Drug-induced hepatitis","Drug-induced psychosis","Dysfunction of sphincter of Oddi","Dyspnea","Epilepsy","Exacerbation of asthma","Factor II deficiency","Familial hyperkalemic periodic paralysis","Fecal impaction","Feeling agitated","Gastritis","Gastroesophageal reflux disease","Gastrointestinal hemorrhage","Gastrointestinal obstruction","Gastrointestinal ulcer","Gastroparesis","Gilles de la Tourette's syndrome","Glaucoma","Gout","Hb SS disease","Heart valve disorder","Hemophilia","Hemorrhoids","Hepatic coma","Hepatic encephalopathy","Hepatic failure","Hyperactive behavior","Hyperammonemia","Hypercalcemia","Hypercapnia","Hyperkalemia","Hypermagnesemia","Hyperparathyroidism","Hypertensive disorder","Hypertensive urgency","Hyperthyroidism","Hypophosphatemia","Hyporeninemic hypoaldosteronism","Hypothyroidism","Hypovolemia","Hypoxia","Impaired cognition","Impaired renal function disorder","Infectious disease of central nervous system","Inflammatory bowel disease","Injury of head","Kidney disease","Kidney stone","Lesion of brain","Leukopenia","Liver function tests abnormal","Low blood pressure","Lowered convulsive threshold","Mania","Mood swings","Morbid obesity","Motor tic disorder","Myasthenia gravis","Myocardial infarction","Myocardial infarction in recovery phase","Myocardial ischemia","Myxedema","Nasal polyp","Necrotizing enterocolitis in fetus OR newborn","Neoplasm of brain","Neutropenic disorder","Obsessive-compulsive disorder","Obstruction of duodenum","Ocular hypertension","Open-angle glaucoma","Operation on gastrointestinal tract","Organic Cardiac Disease","Orthostatic hypotension","Osteolysis","Panic disorder","Paralytic ileus","Partial atrioventricular block","Peptic ulcer","Peripheral nerve disease","Peripheral vascular disease","Pheochromocytoma","Poisoning by acetaminophen","Poisoning by opiate analgesic drug","Poisoning by phenobarbital","Porphyria","Pregnancy, function","Primary adrenocortical insufficiency","Procedure on urinary system","Prolonged PR interval","Prolonged QT interval","Pseudomembranous enterocolitis","Psychiatric Disturbance","Psychotic disorder","Pulmonary emphysema","Pulmonary hypertension","Pyloric obstruction","Raised intracranial pressure","Respiratory insufficiency","Retention of urine","Reye's syndrome","Sarcoidosis","Schizophrenia","Seizure disorder","Serotonin syndrome","Severe Bone Marrow Depression","Severe dehydration","Shock","Sleep apnea","Sleep automatism","Structural disorder of heart","Substance abuse","Suicidal","Suicidal thoughts","Systemic lupus erythematosus","Tachyarrhythmia","Thrombocytopenic disorder","Thrombotic thrombocytopenic purpura","Thyrotoxicosis","Ulcerative colitis","Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant","Unconscious","Urethral stricture","Ventricular tachycardia","Vertigo","Visual impairment","Vitamin K Deficiency Induced Hypoprothrombinemia","Vitamin K deficiency","Weight loss","von Willebrand disorder"]},"trials":["NCT07466771"],"aliases":[],"patents":[],"pricing":[],"allNames":"etamin","offLabel":[],"synonyms":["trolnitrate phosphate","nitranolum","trolnitrate","aminotrate","etamin","nitranole","nitretamine","triethanolamine trinitrate","trolnitrat"],"timeline":[],"aiSummary":"Etamin is a small molecule with the synonyms TROLNITRATE, TROLNITRATE, TROLNITRATO. It has been studied in a randomized controlled trial as part of an art education intervention, specifically cross-stitch training, to improve creativity and mindfulness in midwifery students.","approvals":[],"brandName":"Etamin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Vasodilators Organic Nitrates","explanation":"When nitric oxide is released, it signals the blood vessel muscles to relax, allowing the blood vessel to widen and improve blood flow. This can help to reduce blood pressure and alleviate symptoms of conditions such as angina. The widening of blood vessels also allows more oxygen and nutrients to reach the heart muscle.","oneSentence":"Etamin works by releasing nitric oxide, which relaxes blood vessel muscles and causes blood vessels to widen.","technicalDetail":"Etamin exerts its effects through the release of nitric oxide, which activates guanylate cyclase and increases cyclic guanosine monophosphate (cGMP) levels, leading to smooth muscle relaxation and vasodilation."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Gamma_Draconis","title":"Gamma Draconis","extract":"Gamma Draconis, formally named Eltanin, is a star in the northern constellation of Draco. Contrary to its gamma-designation, it is the brightest object in Draco at magnitude 2.2, outshining Beta Draconis by nearly half a magnitude and Alpha Draconis by over a magnitude."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2770","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TROLNITRATE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Gamma_Draconis","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T16:04:53.257323","biosimilars":[],"competitors":[{"drugName":"glyceryl trinitrate","drugSlug":"glyceryl-trinitrate","fdaApproval":"1981-05-28","relationship":"same-class"},{"drugName":"isosorbide dinitrate","drugSlug":"isosorbide-dinitrate","fdaApproval":"1968-01-16","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"isosorbide mononitrate","drugSlug":"isosorbide-mononitrate","fdaApproval":"1991-12-30","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"trolnitrate","indications":{"approved":[],"offLabel":[{"name":"Fibromyalgia","source":"DrugCentral","drugName":"TROLNITRATE"},{"name":"Vascular headache","source":"DrugCentral","drugName":"TROLNITRATE"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"glyceryl-trinitrate","brandName":"glyceryl trinitrate","genericName":"glyceryl trinitrate","approvalYear":"1981","relationship":"same-class"},{"drugId":"isosorbide-dinitrate","brandName":"isosorbide dinitrate","genericName":"isosorbide dinitrate","approvalYear":"1968","relationship":"same-class"},{"drugId":"isosorbide-mononitrate","brandName":"isosorbide mononitrate","genericName":"isosorbide mononitrate","approvalYear":"1991","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07466771","phase":"NA","title":"The Effects of Art Education on Midwifery Students' Imagination, Individual Creativity, and State Conscious Awareness (Mindfulness): A Randomized Controlled Trial","status":"ENROLLING_BY_INVITATION","sponsor":"Selcuk University","isPivotal":false,"enrollment":110,"indication":"Creativity and Mindfulness","completionDate":"2026-12-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"000690","UNII":"B9M85U075P","CHEBI":"CHEBI:32268","INN_ID":"741","UMLSCUI":"C0077377","ChEMBL_ID":"CHEMBL2111164","DRUGBANK_ID":"DB13719","PUBCHEM_CID":"11499","SNOMEDCT_US":"56227008","SECONDARY_CAS_RN":"588-42-1","MESH_SUPPLEMENTAL_RECORD_UI":"C005873"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01DA09","allCodes":["C01DA09","C01DA59"]},"biosimilarFilings":[],"recentPublications":[{"date":"1966 Feb 15","pmid":"5927953","title":"Protection of rats from isoproterenol induced myocardial necrosis by trolnitrate phosphate (Metamine).","journal":"Experientia"},{"date":"1965 May-Jun","pmid":"4284102","title":"Comparative studies on the mechanism of antianginal action of trolnitrate phosphate and nitroglycerin in animals.","journal":"The Journal of new drugs"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}