{"id":"tritanrix-hiberix-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain, redness, or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability or fussiness"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"The vaccine contains diphtheria and tetanus toxoids (inactivated bacterial toxins) that stimulate antibody production against these toxins, acellular pertussis antigens that trigger immune responses to Bordetella pertussis, and a Haemophilus influenzae type b polysaccharide conjugated to a protein carrier to enhance immunogenicity. This multi-component approach induces both humoral and cellular immunity to prevent these four serious bacterial infections.","oneSentence":"Tritanrix/Hiberix is a combination vaccine that provides immunization against diphtheria, tetanus, pertussis, and Haemophilus influenzae type b through inactivated toxoids and conjugate antigens.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:54:35.044Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of diphtheria, tetanus, pertussis, and Haemophilus influenzae type b infection in infants and children"}]},"trialDetails":[{"nctId":"NCT00136604","phase":"PHASE3","title":"Response to GSK Biologicals' Tritanrix-HepB/Hib-MenAC Vacc (4th Dose) at 15-24m & Mencevax ACWY at 24-30m","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-01-22","conditions":"Whole Cell Pertussis, Haemophilus Influenzae Type b, Hepatitis 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Used for Prevention of diphtheria, tetanus, pertussis, and Haemophilus influenzae type b infection in infants and children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}