{"id":"trisodium-citrate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypocalcemia (when used systemically)"},{"rate":null,"effect":"Gastrointestinal upset (oral formulation)"},{"rate":null,"effect":"Hypernatremia (sodium overload)"}]},"_chembl":{"chemblId":"CHEMBL2096651","moleculeType":"Small molecule","molecularWeight":"755.31"},"_dailymed":{"setId":"7025a0f9-1a56-4416-a3a4-925d755aed90","title":"ANTICOAGULANT SODIUM CITRATE (TRISODIUM CITRATE DIHYDRATE) SOLUTION [BAXTER HEALTHCARE CORPORATION]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Trisodium citrate binds ionized calcium (Ca2+) in blood, reducing the concentration of free calcium below the threshold required for the coagulation cascade to proceed. This makes it useful as an anticoagulant in blood collection tubes, hemodialysis circuits, and other extracorporeal blood handling procedures. It is also used orally as an alkalinizing agent to treat metabolic acidosis and prevent kidney stone formation.","oneSentence":"Trisodium citrate acts as an anticoagulant by chelating calcium ions, preventing blood clotting in vitro and in extracorporeal circuits.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:14:45.693Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anticoagulation in blood collection tubes and extracorporeal circuits (hemodialysis, apheresis)"},{"name":"Oral treatment of metabolic acidosis and prevention of kidney stone formation"}]},"trialDetails":[{"nctId":"NCT02466971","phase":"PHASE3","title":"Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2016-05-10","conditions":"Advanced Vaginal Adenocarcinoma, 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