{"id":"triptorelin-i-n-n","safety":{"commonSideEffects":[{"rate":"50–80","effect":"Hot flashes"},{"rate":"10–30","effect":"Injection site reaction"},{"rate":"5–15","effect":"Headache"},{"rate":"5–15","effect":"Fatigue"},{"rate":"10–20","effect":"Decreased libido"},{"rate":"10–20","effect":"Erectile dysfunction"},{"rate":"5–10","effect":"Gynecomastia"}]},"_chembl":{"chemblId":"CHEMBL1200554","moleculeType":"Protein","molecularWeight":"1699.85"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Triptorelin binds to GnRH receptors in the anterior pituitary, initially triggering release of LH and FSH. With continuous exposure, the pituitary becomes desensitized and downregulates GnRH receptors, resulting in suppression of gonadal sex hormone production (testosterone in males, estrogen in females). This sustained suppression is therapeutically useful in hormone-dependent conditions.","oneSentence":"Triptorelin is a GnRH agonist that stimulates the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, initially increasing sex hormone levels before causing sustained suppression through receptor desensitization.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:08.843Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced prostate cancer"},{"name":"Endometriosis"},{"name":"Uterine fibroids"},{"name":"Central precocious puberty"}]},"trialDetails":[{"nctId":"NCT00909844","phase":"PHASE3","title":"Effects of Triptorelin Pamoate in Children With Precocious Puberty - Follow up Study","status":"COMPLETED","sponsor":"Ipsen","startDate":"2008-04","conditions":"Precocious Puberty","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Triptorelin (I.N.N.)","genericName":"Triptorelin (I.N.N.)","companyName":"Ipsen","companyId":"ipsen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triptorelin is a GnRH agonist that stimulates the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, initially increasing sex hormone levels before causing sustained suppression through receptor desensitization. Used for Advanced prostate cancer, Endometriosis, Uterine fibroids.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}