{"id":"triptorelin-acetate-hcg","safety":{"commonSideEffects":[{"rate":null,"effect":"Hot flashes"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Decreased libido"}]},"_chembl":{"chemblId":"CHEMBL5315073","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Triptorelin acetate acts as a gonadotropin-releasing hormone (GnRH) agonist, initially stimulating then desensitizing GnRH receptors on the pituitary gland to suppress LH and FSH secretion. When combined with hCG (human chorionic gonadotropin), this formulation may be used to support fertility outcomes or ovarian stimulation protocols, leveraging both the suppressive effects of triptorelin and the stimulatory effects of exogenous hCG.","oneSentence":"Triptorelin is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production, combined with hCG for fertility preservation or ovarian stimulation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:14:36.048Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fertility preservation or ovarian stimulation in assisted reproductive technology"},{"name":"Prostate cancer (standard triptorelin indication, though hCG combination is less common)"}]},"trialDetails":[{"nctId":"NCT06481696","phase":"NA","title":"Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertility","status":"RECRUITING","sponsor":"Andros Day Surgery Clinic","startDate":"2024-06-01","conditions":"Unexplained Infertility","enrollment":90},{"nctId":"NCT05567731","phase":"NA","title":"Effect of GnRH Agonist Treatment Protocols on Ovarian Reserve","status":"COMPLETED","sponsor":"Tanta University","startDate":"2022-10-15","conditions":"Intracytoplasmic Sperm Injection, GnRH Agonist, Infertility","enrollment":30},{"nctId":"NCT04724486","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI","status":"COMPLETED","sponsor":"Damascus University","startDate":"2020-08-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT04724343","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2019-12-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT04727684","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI","status":"COMPLETED","sponsor":"Damascus University","startDate":"2020-08-22","conditions":"In Vitro Fertilization, Infertility, Intracytoplasmic Sperm Injection","enrollment":50},{"nctId":"NCT04727671","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2019-12-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT05321511","phase":"PHASE4","title":"Comparison of Triggers in Double Ovarian Stimulation (DuoStim).","status":"UNKNOWN","sponsor":"Instituto Bernabeu","startDate":"2022-03-03","conditions":"IVF, LOW OVARIAN RESPONSE","enrollment":165},{"nctId":"NCT04717752","phase":"NA","title":"A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve","status":"UNKNOWN","sponsor":"Nanjing University","startDate":"2021-01-20","conditions":"Poor Ovarian Response","enrollment":310},{"nctId":"NCT04407065","phase":"PHASE2","title":"Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles","status":"UNKNOWN","sponsor":"Riyadh Fertility and Reproductive Health center","startDate":"2020-05-30","conditions":"Infertility, Female","enrollment":56},{"nctId":"NCT04407052","phase":"PHASE2","title":"Double Trigger in Patients With Low Proportion of Mature Oocytes","status":"UNKNOWN","sponsor":"Riyadh Fertility and Reproductive Health center","startDate":"2020-05-30","conditions":"Infertility, Female","enrollment":66},{"nctId":"NCT03809221","phase":"PHASE4","title":"The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation","status":"UNKNOWN","sponsor":"Peking University People's Hospital","startDate":"2019-02-01","conditions":"Infertility, Female","enrollment":1892},{"nctId":"NCT01638026","phase":"PHASE4","title":"Final Oocyte Maturation Via Administration of GnRH Agonists Followed By Luteal Support With hCG","status":"COMPLETED","sponsor":"HaEmek Medical Center, Israel","startDate":"2012-09","conditions":"Infertility","enrollment":93},{"nctId":"NCT02825290","phase":"PHASE4","title":"Modified Luteal Support for Frozen-Thawed Embryo Transfer - A Prospective Study","status":"UNKNOWN","sponsor":"Sheba Medical Center","startDate":"2016-07","conditions":"Embryo Transfer, Luteal Support","enrollment":62},{"nctId":"NCT01590173","phase":"PHASE2, PHASE3","title":"Addition of Prednisolone and Heparin in Patients Undergoing IVF With Failed IVF Cycles","status":"COMPLETED","sponsor":"National and Kapodistrian University of Athens","startDate":"2012-01","conditions":"Infertility","enrollment":86},{"nctId":"NCT01798862","phase":"PHASE2, PHASE3","title":"Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles","status":"COMPLETED","sponsor":"National and Kapodistrian University of Athens","startDate":"2013-03","conditions":"Repeated Implantation Failures","enrollment":100},{"nctId":"NCT01979341","phase":"NA","title":"The Effect of a Dual Trigger on Intracytoplasmic Sperm Injection (ICSI) Reproductive Outcomes","status":"WITHDRAWN","sponsor":"Antalya IVF","startDate":"2013-10","conditions":"Pregnancy, Ovarian Hyperstimulation Syndrome","enrollment":""},{"nctId":"NCT02461875","phase":"PHASE2","title":"Cabergoline Versus GnRH Antagonist Rescue and Cabergoline in the Prevention of Ovarian Hyperstimulation Syndrome","status":"UNKNOWN","sponsor":"Aljazeera Hospital","startDate":"2013-05","conditions":"OHSS","enrollment":236},{"nctId":"NCT02442895","phase":"","title":"Biomarkers of Ovarian Reserve and Correlation With IVF Treatments","status":"COMPLETED","sponsor":"U.O.S. Procreazione Medicalmente Assistita e Congelamento Gameti","startDate":"2014-02","conditions":"Pregnancy, Ovarian","enrollment":236}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"TRIPTORELIN ACETATE, hCG","genericName":"TRIPTORELIN ACETATE, hCG","companyName":"HaEmek Medical Center, Israel","companyId":"haemek-medical-center-israel","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triptorelin is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production, combined with hCG for fertility preservation or ovarian stimulation. Used for Fertility preservation or ovarian stimulation in assisted reproductive technology, Prostate cancer (standard triptorelin indication, though hCG combination is less common).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}