{"id":"triptolide-wilfordii","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by inhibiting the production of pro-inflammatory cytokines and suppressing the activity of immune cells, leading to a reduction in inflammation and immune response. This mechanism of action is thought to contribute to its therapeutic effects in treating various diseases.","oneSentence":"Triptolide Wilfordii is a diterpenoid epoxide derived from the Chinese herb Tripterygium wilfordii, which has anti-inflammatory and immunosuppressive properties.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:54:31.530Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT03403569","phase":"PHASE3","title":"Safety and Efficacy of Triptolide Wilfordii in New Onset HIV-1 Infection","status":"COMPLETED","sponsor":"Peking Union Medical College Hospital","startDate":"2018-09-01","conditions":"HIV-infection/AIDS","enrollment":353},{"nctId":"NCT00801268","phase":"NA","title":"Randomized Clinical Trial of Triptolide Woldifii for Autosomal Dominant Polycystic Kidney Disease","status":"TERMINATED","sponsor":"Zhi-Hong Liu, M.D.","startDate":"2008-11","conditions":"Polycystic Kidney","enrollment":300},{"nctId":"NCT02219672","phase":"PHASE3","title":"Study on the Impact of Triptolide Woldifiion on HIV-1 Reservoir In Acute HIV-1 Infection","status":"UNKNOWN","sponsor":"Peking Union Medical College","startDate":"2014-07","conditions":"AIDS/HIV PROBLEM","enrollment":18},{"nctId":"NCT02002286","phase":"NA","title":"Safety and Efficacy Study of TwHF in HIV Patients With Poor Immune Responses","status":"COMPLETED","sponsor":"LI Taisheng","startDate":"2011-08","conditions":"HIV","enrollment":23},{"nctId":"NCT01817283","phase":"PHASE1, PHASE2","title":"Impact on T Cell Immune Activation and Inflammation of Triptolide Woldifii in HIV-infected Immunological Non-responders","status":"UNKNOWN","sponsor":"LI Taisheng","startDate":"2013-01","conditions":"HIV","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":702,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Triptolide Wilfordii","genericName":"Triptolide Wilfordii","companyName":"Peking Union Medical College Hospital","companyId":"peking-union-medical-college-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triptolide is a small molecule with the synonyms NSC-163062 and TRIPTOLIDE, extracted from Tripterygium Wilfordii Hook F. It has been studied in clinical trials for conditions such as HIV, AIDS/HIV PROBLEM, HIV-infection/AIDS, and Polycystic Kidney disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}