{"id":"tripterygium-wilfordii","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Bone marrow suppression"},{"rate":null,"effect":"Reproductive toxicity"}]},"_chembl":null,"_dailymed":{"setId":"655270c0-3e00-4f81-8d18-611fac91c8ca","title":"PAMO KILL NATURAL (TRIPTERYGIUM WILFORDII WHOLE) LIQUID [GEORIM PHARMACEUTICAL]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The plant extract contains multiple bioactive compounds (triptolide and other diterpenoids) that inhibit T cell proliferation, reduce pro-inflammatory cytokine secretion (TNF-α, IL-6, IL-8), and modulate immune responses. It acts as a broad immunosuppressant and anti-inflammatory agent, making it useful in autoimmune and inflammatory conditions.","oneSentence":"Tripterygium wilfordii extract suppresses immune cell activation and reduces inflammatory cytokine production through multiple pathways including NF-κB inhibition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:14:43.147Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Systemic lupus erythematosus"},{"name":"Other autoimmune and inflammatory disorders"}]},"trialDetails":[{"nctId":"NCT04981613","phase":"NA","title":"Study on the Efficacy and Safety of a Novel Tripterygium Wilfordii Preparation in Reducing Proteinuria in Patients With Diabetic Nephropathy","status":"COMPLETED","sponsor":"First Affiliated Hospital Xi'an Jiaotong University","startDate":"2021-07-28","conditions":"Diabetic Nephropathy","enrollment":80},{"nctId":"NCT03589833","phase":"PHASE4","title":"Effectiveness and Safety of Yisaipu Combined With Tripterygium Wilfordii for Active RA","status":"COMPLETED","sponsor":"Peking Union Medical College Hospital","startDate":"2019-05-14","conditions":"Arthritis, Rheumatoid","enrollment":504},{"nctId":"NCT05393050","phase":"PHASE4","title":"Efficacy and Safety of Colquhounia Root Tablet in Patients With Rheumatoid Arthritis","status":"UNKNOWN","sponsor":"Quan Jiang","startDate":"2022-07","conditions":"Rheumatoid Arthritis","enrollment":120},{"nctId":"NCT04136262","phase":"PHASE2, PHASE3","title":"Tripterygium Wilfordii Hook F and Methotrexate for Postmenopausal Women With Rheumatoid Arthritis","status":"UNKNOWN","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2019-11-25","conditions":"Rheumatoid Arthritis","enrollment":300},{"nctId":"NCT04066803","phase":"PHASE4","title":"Optimal MTX Dose With Folic Acid Randomized Case-control Trial","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2018-08-01","conditions":"Rheumatoid Arthritis","enrollment":160},{"nctId":"NCT02878018","phase":"","title":"Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis","status":"UNKNOWN","sponsor":"Liaoning University of Traditional Chinese Medicine","startDate":"2016-09","conditions":"Henoch-Schonlein Purpura Nephritis","enrollment":600},{"nctId":"NCT02818361","phase":"NA","title":"Topical Tripterygium Wilfordii Gel for Moderate Activity Rheumatoid Arthritis","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2012-04","conditions":"Arthritis, Rheumatoid","enrollment":70},{"nctId":"NCT03591471","phase":"PHASE1, PHASE2","title":"Study on Children Henoch-Schönlein Purpura Nephritis With TCM Multistep Treatment","status":"UNKNOWN","sponsor":"Henan University of Traditional Chinese Medicine","startDate":"2014-09","conditions":"Henoch-Schönlein Purpura Nephritis","enrollment":500},{"nctId":"NCT03337815","phase":"PHASE2, PHASE3","title":"A Specification Clinical Application Research of Tripterygium Wilfordii Treating Rheumatoid Arthritis","status":"UNKNOWN","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2017-10-28","conditions":"Rheumatoid Arthritis","enrollment":264},{"nctId":"NCT03324412","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of TwHF and MTX in Patients With Rheumatoid Arthritis","status":"UNKNOWN","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2017-10-28","conditions":"Rheumatoid Arthritis","enrollment":216},{"nctId":"NCT01961505","phase":"NA","title":"Topical Compound Tripterygium Wilfordii Hook F for Patients With Active Rheumatoid Arthritis","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2011-10","conditions":"Active Rheumatoid Arthritis","enrollment":70},{"nctId":"NCT02764515","phase":"PHASE4","title":"Kunxian for the Treatment of Rheumatoid Arthritis","status":"UNKNOWN","sponsor":"Chinese SLE Treatment And Research Group","startDate":"2015-09","conditions":"Rheumatoid Arthritis","enrollment":428},{"nctId":"NCT01666990","phase":"PHASE1, PHASE2","title":"Tripterygium Wilfordii Hook F (TwHF) Treatment for Immune Non-responders With HIV-1 Infection","status":"UNKNOWN","sponsor":"Beijing 302 Hospital","startDate":"2012-06","conditions":"Human Immunodeficiency Virus","enrollment":60},{"nctId":"NCT00885547","phase":"NA","title":"Prospective Study of TW in Treatment of IgAN With Asymptomatic Abnormal Urinalysis","status":"TERMINATED","sponsor":"Nanjing University School of Medicine","startDate":"2009-03","conditions":"IgA Nephropathy","enrollment":90},{"nctId":"NCT00801268","phase":"NA","title":"Randomized Clinical Trial of Triptolide Woldifii for Autosomal Dominant Polycystic Kidney Disease","status":"TERMINATED","sponsor":"Zhi-Hong Liu, M.D.","startDate":"2008-11","conditions":"Polycystic Kidney","enrollment":300},{"nctId":"NCT02219672","phase":"PHASE3","title":"Study on the Impact of Triptolide Woldifiion on HIV-1 Reservoir In Acute HIV-1 Infection","status":"UNKNOWN","sponsor":"Peking Union Medical College","startDate":"2014-07","conditions":"AIDS/HIV PROBLEM","enrollment":18},{"nctId":"NCT02187900","phase":"PHASE3","title":"Treatment of IgAN With Multi-glycoside of Tripterygium Wilfordii HOOK. f.","status":"UNKNOWN","sponsor":"Second Xiangya Hospital of Central South University","startDate":"2014-06","conditions":"IgA Nephropathy","enrollment":300},{"nctId":"NCT01161459","phase":"NA","title":"Treatment of Idiopathic Membranous Nephropathy With Tripterygium Wilfordii Plus Steroid vs Tacrolimus Plus Steroid","status":"COMPLETED","sponsor":"Zhi-Hong Liu, M.D.","startDate":"2010-06","conditions":"Idiopathic Membranous Nephropathy","enrollment":100},{"nctId":"NCT02044952","phase":"PHASE2, PHASE3","title":"Efficacy and Safety Study of Tripterygium Glycoside in the Treatment of Crohn's Disease for Induction Remission","status":"UNKNOWN","sponsor":"Zhu Weiming","startDate":"2014-01","conditions":"Inflammatory Bowel Diseases, Crohn's Disease, Gastrointestinal Diseases","enrollment":40},{"nctId":"NCT02002286","phase":"NA","title":"Safety and Efficacy Study of TwHF in HIV Patients With Poor Immune Responses","status":"COMPLETED","sponsor":"LI Taisheng","startDate":"2011-08","conditions":"HIV","enrollment":23},{"nctId":"NCT01613079","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of Tripterygium Wilfordii in Patients With Rheumatoid Arthritis","status":"COMPLETED","sponsor":"Peking Union Medical College Hospital","startDate":"2012-05","conditions":"Arthritis, Rheumatoid","enrollment":201},{"nctId":"NCT01820247","phase":"NA","title":"Efficacy Study of Tripterygium Glycoside Combined With Enteral Nutrition in the Treatment of Crohn's Disease for Induction Remission","status":"UNKNOWN","sponsor":"Zhu Weiming","startDate":"2012-12","conditions":"Crohn's Disease","enrollment":100},{"nctId":"NCT01817283","phase":"PHASE1, PHASE2","title":"Impact on T Cell Immune Activation and Inflammation of Triptolide Woldifii in HIV-infected Immunological Non-responders","status":"UNKNOWN","sponsor":"LI Taisheng","startDate":"2013-01","conditions":"HIV","enrollment":150},{"nctId":"NCT01646736","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of Tripterygium Wilfordii in Patients With Lupus Nephritis","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2012-07","conditions":"Nephritis, Lupus","enrollment":130},{"nctId":"NCT00953979","phase":"PHASE4","title":"Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis","status":"COMPLETED","sponsor":"Gu Jieruo","startDate":"2008-01","conditions":"Ankylosing Spondylitis, Treatment","enrollment":126},{"nctId":"NCT00935389","phase":"NA","title":"Prospective Study of TW in the Treatment of LN Type V With Gross Proteinuria","status":"COMPLETED","sponsor":"Nanjing University School of Medicine","startDate":"2009-04","conditions":"Lupus Nephritis, Proteinuria, CTX","enrollment":44},{"nctId":"NCT00881309","phase":"NA","title":"To Compare the Efficacy and Safety of Tripterygium (TW) Versus AZA in the Maintenance Therapy for Lupus Nephritis","status":"COMPLETED","sponsor":"Nanjing University School of Medicine","startDate":"2009-03","conditions":"Lupus Nephritis","enrollment":94},{"nctId":"NCT00801463","phase":"NA","title":"Prednisone Plus Tripterygium Wilfordii Treatment of Adult Patients With Idiopathic Focal Segmental Glomerulosclerosis","status":"COMPLETED","sponsor":"Nanjing University School of Medicine","startDate":"2009-01","conditions":"Proteinuria, Focal Segmental Glomerulosclerosis","enrollment":67},{"nctId":"NCT00518219","phase":"PHASE4","title":"To Compare the Efficacy and Safety of Tripterygium Wilfordii (TW) Versus Valsartan in the Membranous Nephropathy (MN)","status":"COMPLETED","sponsor":"Nanjing University School of Medicine","startDate":"2007-07","conditions":"Membranous Nephropathy","enrollment":68},{"nctId":"NCT00518362","phase":"NA","title":"To Compare the Efficacy and Safety of Tripterygium (TW) Versus Valsartan in the Diabetic Nephropathy (DN)","status":"COMPLETED","sponsor":"Nanjing University School of Medicine","startDate":"2007-07","conditions":"Diabetic Nephropathy","enrollment":67},{"nctId":"NCT00889694","phase":"PHASE2, PHASE3","title":"Clinical Study of Tripterygium Capsule to Treat Early Ankylosing Spondylitis","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2008-10","conditions":"Early Ankylosing Spondylitis","enrollment":80},{"nctId":"NCT00062465","phase":"PHASE2","title":"Treating Rheumatoid Arthritis With Tripterygium Wilfordi Hook F or Sulfasalazine","status":"COMPLETED","sponsor":"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","startDate":"2003-06","conditions":"Rheumatoid Arthritis","enrollment":157}],"_emaApprovals":[],"_faersSignals":[{"count":5,"reaction":"OFF LABEL USE"},{"count":3,"reaction":"DERMATITIS"},{"count":3,"reaction":"DRUG ERUPTION"},{"count":3,"reaction":"DRUG INEFFECTIVE"},{"count":3,"reaction":"PNEUMONIA"},{"count":2,"reaction":"DRUG INEFFECTIVE FOR UNAPPROVED INDICATION"},{"count":2,"reaction":"INTENTIONAL PRODUCT USE ISSUE"},{"count":2,"reaction":"NAUSEA"},{"count":2,"reaction":"PROTEINURIA"},{"count":2,"reaction":"RENAL FAILURE ACUTE"}],"_approvalHistory":[],"publicationCount":1825,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TW"],"phase":"marketed","status":"active","brandName":"tripterygium wilfordii","genericName":"tripterygium wilfordii","companyName":"Zhi-Hong Liu, M.D.","companyId":"zhi-hong-liu-m-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tripterygium wilfordii extract suppresses immune cell activation and reduces inflammatory cytokine production through multiple pathways including NF-κB inhibition. Used for Rheumatoid arthritis, Systemic lupus erythematosus, Other autoimmune and inflammatory disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}