{"id":"triptergium-wilfordii","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Bone marrow suppression"},{"rate":null,"effect":"Reproductive toxicity"},{"rate":null,"effect":"Amenorrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The plant extract contains multiple bioactive compounds (triptolide and other diterpenoids) that inhibit T cell proliferation, reduce pro-inflammatory cytokine secretion (TNF-α, IL-2, IL-6), and modulate immune responses. It acts as a broad immunosuppressant and anti-inflammatory agent, making it useful in autoimmune and inflammatory conditions.","oneSentence":"Triptergium wilfordii extract suppresses immune cell activation and reduces inflammatory cytokine production through multiple pathways including NF-κB inhibition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:12.687Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Systemic lupus erythematosus"},{"name":"Nephrotic syndrome"},{"name":"Other autoimmune and inflammatory diseases"}]},"trialDetails":[{"nctId":"NCT01443338","phase":"PHASE4","title":"Study Evaluating the Efficacy and Safety of Triptergium Wilfordii and Acitretin in Psoriasis Vulgaris - CHINA201002016-2","status":"UNKNOWN","sponsor":"Ministry of Health, China","startDate":"2011-09","conditions":"Psoriasis Vulgaris","enrollment":720}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":26,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Triptergium Wilfordii","genericName":"Triptergium Wilfordii","companyName":"Ministry of Health, China","companyId":"ministry-of-health-china","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triptergium wilfordii extract suppresses immune cell activation and reduces inflammatory cytokine production through multiple pathways including NF-κB inhibition. Used for Rheumatoid arthritis, Systemic lupus erythematosus, Nephrotic syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}