{"id":"trimetazidine-mimic","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Asthenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Trimetazidine mimics the mechanism of action of trimetazidine, a selective inhibitor of the last enzyme in mitochondrial beta-oxidation of long-chain fatty acids. By blocking this enzyme, the drug forces cardiomyocytes to rely more on glucose oxidation for ATP production, which is more oxygen-efficient and beneficial during ischemia or heart failure. This metabolic shift improves cardiac contractility and reduces ischemic injury without hemodynamic side effects.","oneSentence":"This drug inhibits mitochondrial long-chain 3-ketoacyl-CoA thiolase (LC3KAT) to shift cardiac energy metabolism from fatty acid oxidation to glucose oxidation, improving myocardial efficiency without affecting heart rate or blood pressure.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:14:39.916Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Angina pectoris"},{"name":"Heart failure"}]},"trialDetails":[{"nctId":"NCT03809273","phase":"PHASE4","title":"Effects of Yangxinshi Pills on the Exercise Tolerance Compared With Trimetazidine in Patients After PCI","status":"COMPLETED","sponsor":"Shenyang Northern Hospital","startDate":"2019-08-01","conditions":"Percutaneous Coronary Intervention","enrollment":681}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Trimetazidine mimic","genericName":"Trimetazidine mimic","companyName":"Shenyang Northern Hospital","companyId":"shenyang-northern-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This drug inhibits mitochondrial long-chain 3-ketoacyl-CoA thiolase (LC3KAT) to shift cardiac energy metabolism from fatty acid oxidation to glucose oxidation, improving myocardial efficiency without affecting heart rate or blood pressure. Used for Angina pectoris, Heart failure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}