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This can be beneficial for women who want to avoid pregnancy, but more research is needed to understand its full effects on the body.","oneSentence":"Trimegestone is a synthetic steroid that acts as a selective progesterone receptor modulator.","technicalDetail":"Trimegestone exerts its effects by selectively binding to the progesterone receptor, which can influence gene expression and cellular signaling pathways involved in reproductive processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4736","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TRIMEGESTONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TRIMEGESTONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:08:40.330353","biosimilars":[],"competitors":[{"drugName":"norethisterone","drugSlug":"norethisterone","fdaApproval":"1962-05-21","relationship":"same-class"},{"drugName":"hydroxyprogesterone caproate","drugSlug":"hydroxyprogesterone-caproate","fdaApproval":"1975-10-03","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"progesterone","drugSlug":"progesterone","fdaApproval":"1976-02-04","patentExpiry":"Jan 21, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"etynodiol","drugSlug":"etynodiol","fdaApproval":"1966-03-23","relationship":"same-class"},{"drugName":"megestrol acetate","drugSlug":"megestrol-acetate","fdaApproval":"1971-08-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"norethynodrel","drugSlug":"norethynodrel","fdaApproval":"1961-03-09","relationship":"same-class"},{"drugName":"levonorgestrel","drugSlug":"levonorgestrel","fdaApproval":"1968-04-16","patentExpiry":"Sep 7, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"medroxyprogesterone","drugSlug":"medroxyprogesterone","fdaApproval":"1959-06-18","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"norgestimate","drugSlug":"norgestimate","fdaApproval":"1989-12-29","relationship":"same-class"},{"drugName":"dydrogesterone","drugSlug":"dydrogesterone","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"dienogest","drugSlug":"dienogest","fdaApproval":"2010-05-06","relationship":"same-class"},{"drugName":"drospirenone","drugSlug":"drospirenone","fdaApproval":"2019-05-23","patentExpiry":"Jun 28, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"trimegestone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"norethisterone","brandName":"norethisterone","genericName":"norethisterone","approvalYear":"1962","relationship":"same-class"},{"drugId":"hydroxyprogesterone-caproate","brandName":"hydroxyprogesterone caproate","genericName":"hydroxyprogesterone caproate","approvalYear":"1975","relationship":"same-class"},{"drugId":"progesterone","brandName":"progesterone","genericName":"progesterone","approvalYear":"1976","relationship":"same-class"},{"drugId":"etynodiol","brandName":"etynodiol","genericName":"etynodiol","approvalYear":"1966","relationship":"same-class"},{"drugId":"megestrol-acetate","brandName":"megestrol acetate","genericName":"megestrol acetate","approvalYear":"1971","relationship":"same-class"},{"drugId":"norethynodrel","brandName":"norethynodrel","genericName":"norethynodrel","approvalYear":"1961","relationship":"same-class"},{"drugId":"levonorgestrel","brandName":"levonorgestrel","genericName":"levonorgestrel","approvalYear":"1968","relationship":"same-class"},{"drugId":"medroxyprogesterone","brandName":"medroxyprogesterone","genericName":"medroxyprogesterone","approvalYear":"1959","relationship":"same-class"},{"drugId":"norgestimate","brandName":"norgestimate","genericName":"norgestimate","approvalYear":"1989","relationship":"same-class"},{"drugId":"dydrogesterone","brandName":"dydrogesterone","genericName":"dydrogesterone","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03343912","phase":"PHASE1","title":"Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vaginal Rings","status":"COMPLETED","sponsor":"Galeno Desenvolvimento de Pesquisas Clínicas","startDate":"2017-11-10","conditions":["Pregnancy"],"enrollment":36,"completionDate":"2018-02-15"},{"nctId":"NCT00472004","phase":"PHASE4","title":"Study Comparing 17B Estradiol/TMG CC 1mg Vs. Tibolone In Postmenopausal Women","status":"COMPLETED","sponsor":"Wyeth is now a wholly owned subsidiary of Pfizer","startDate":"2006-02","conditions":["Vasomotor Symptoms"],"enrollment":204,"completionDate":"2009-12"},{"nctId":"NCT00195455","phase":"PHASE4","title":"Study Evaluating Estradiol/Trimegestone in Vasomotor Symptoms (VMS) in Post-Menopausal Women.","status":"COMPLETED","sponsor":"Wyeth is now a wholly owned subsidiary of Pfizer","startDate":"2005-02","conditions":["Postmenopause"],"enrollment":133,"completionDate":"2007-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"015322","UNII":"4658K0H08W","CHEBI":"CHEBI:136027","INN_ID":"6897","UMLSCUI":"C0628822","ChEMBL_ID":"CHEMBL2104765","KEGG_DRUG":"D06235","DRUGBANK_ID":"DB13129","PUBCHEM_CID":"68926","MESH_SUPPLEMENTAL_RECORD_UI":"C050319"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03FA16","allCodes":["G03FA16","G03FB11"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trimegestone is a small molecule that acts as a progesterone receptor agonist. It is classified as a drug that belongs to the agonist class, specifically targeting the progesterone receptor.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}