{"id":"trifolium-pratense","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Muscle aches"}]},"_chembl":{"chemblId":"CHEMBL2108933","moleculeType":"Unknown"},"_dailymed":{"setId":"dbe965b3-e81e-4328-bc41-43e875e12a05","title":"DENTOX (BERBERIS VULGARIS, GLYCYRRHIZA GLABRA, LAPPA MAJOR, STILLINGIA SYLVATICA, TRIFOLIUM PRATENSE, PHYTOLACCA DECANDRA, LYMPH NODE(SUIS), MEDULLA OSSIS SUIS, THYMUS (SUIS), THYROIDINUM (SUIS), CALCAREA FLUORICA, NATRUM FLUORATUM, ARGENTUM METALLICUM, AURUM METALLICUM, CUPRUM METALLICUM, EUGENOL, FORMALINUM, LIDOCAINE, MERCURIUS SOLUBILIS, MOLYBDENUM, NICCOLUM METALLICUM, PALLADIUM METALLICUM, STANNUM METALLICUM, TITANIUM METALLICUM, ZINCUM METALLICUM) LIQUID [BIOACTIVE NUTRITIONAL, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Red clover is rich in isoflavones (genistein, daidzein, formononetin, biochanin A) that have structural similarity to estradiol and can bind estrogen receptors with varying affinity. These phytoestrogens may exert selective estrogen receptor modulator (SERM)-like effects, potentially influencing bone metabolism, vasomotor symptoms, and cardiovascular function. The mechanism remains incompletely characterized and effects are generally modest.","oneSentence":"Trifolium pratense (red clover) contains isoflavones that may act as phytoestrogens, binding to estrogen receptors to modulate hormonal signaling.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:11:21.626Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal hot flashes and night sweats"},{"name":"Bone health and osteoporosis prevention"},{"name":"Cardiovascular health support"}]},"trialDetails":[{"nctId":"NCT07182370","phase":"NA","title":"Polyphenol Metabolism and Personalized Nutrition in Menopause (PolyPause).","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Research Council, Spain","startDate":"2024-01-15","conditions":"Menopause Related Conditions, Cardiovascular Risk","enrollment":90},{"nctId":"NCT06209697","phase":"NA","title":"Effect of Red Clover on Menopause Symptoms and Lipid Profile","status":"COMPLETED","sponsor":"Medipol University","startDate":"2022-03-20","conditions":"Menopause","enrollment":82},{"nctId":"NCT02174666","phase":"NA","title":"Isoflavone Treatment for Postmenopausal Osteopenia.","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2014-06","conditions":"Osteopenia, Osteoporosis","enrollment":85},{"nctId":"NCT05013593","phase":"NA","title":"Red Clover Isoflavones in Postmenopausal Women With Urge Urinary Incontinence and Overactive Bladder","status":"COMPLETED","sponsor":"Regionshospital Nordjylland","startDate":"2019-07-15","conditions":"Urge Incontinence, Overactive Bladder","enrollment":108},{"nctId":"NCT02264223","phase":"NA","title":"The Bioavailability of Red Clover Isoflavones","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2014-10","conditions":"Healthy","enrollment":16},{"nctId":"NCT03205787","phase":"NA","title":"Red Clover Botanical Dietary Supplements - Metabolism and Safety in Women","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2017-09-21","conditions":"Food-drug Interaction","enrollment":20},{"nctId":"NCT04154306","phase":"NA","title":"Effects of Fermented Red Clover on Muscle Strength and Muscle Mass","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2019-11-01","conditions":"Estrogen Deficiency","enrollment":10},{"nctId":"NCT03844685","phase":"PHASE2","title":"Red Clover and Lifestyle Changes to Contrast Menopausal Symptoms in Premenopausal Breast Cancer Patients Given Tamoxifen","status":"COMPLETED","sponsor":"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano","startDate":"2012-07-05","conditions":"Breast Cancer","enrollment":88},{"nctId":"NCT02028702","phase":"NA","title":"Alternative Treatments for Menopausal Women","status":"COMPLETED","sponsor":"Aarhus University Hospital","startDate":"2012-06","conditions":"Menopause, Hot Flushes, Osteoporosis","enrollment":61},{"nctId":"NCT01497977","phase":"PHASE4","title":"Phytoestrogen Supplementation in Postmenopausal Women","status":"COMPLETED","sponsor":"American Medical Academy, Serbia","startDate":"2008-09","conditions":"Low Serum Lipid Levels","enrollment":74},{"nctId":"NCT01116310","phase":"PHASE4","title":"Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause","status":"UNKNOWN","sponsor":"Laboratorios Casen-Fleet S.L.U.","startDate":"2010-04","conditions":"Postmenopausal Women With Moderate Vasomotor Symptoms","enrollment":166},{"nctId":"NCT00066144","phase":"PHASE2","title":"Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms","status":"COMPLETED","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2003-04","conditions":"Hot Flashes, Menopause","enrollment":112},{"nctId":"NCT00010959","phase":"PHASE1","title":"Single-Dose Study of Black Cohosh and Red Clover","status":"COMPLETED","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2001-02","conditions":"Menopause","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Trifolium pratense","genericName":"Trifolium pratense","companyName":"National Center for Complementary and Integrative Health (NCCIH)","companyId":"national-center-for-complementary-and-integrative-health-nccih","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trifolium pratense (red clover) contains isoflavones that may act as phytoestrogens, binding to estrogen receptors to modulate hormonal signaling. Used for Menopausal hot flashes and night sweats, Bone health and osteoporosis prevention, Cardiovascular health support.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}