{"id":"triflusal","rwe":[],"tags":[{"label":"triflusal","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B01AC18","category":"atc"},{"label":"Active","category":"status"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Platelet Aggregation Inhibitors","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"disgren","offLabel":[],"synonyms":["triflusal","disgren"],"timeline":[],"approvals":[],"brandName":"Disgren","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"triflusal","explanation":"Imagine your blood is made up of tiny cells called platelets that help your body stop bleeding when you get hurt. Disgren helps prevent these platelets from sticking together and forming clots, which can reduce the risk of heart attacks and strokes. This is done by blocking the production of a chemical called thromboxane A2, which is involved in the process of platelet aggregation.","oneSentence":"Disgren works by inhibiting platelet aggregation through the inhibition of thromboxane A2 synthesis.","technicalDetail":"Triflusal exerts its antiplatelet effects by competitively inhibiting the enzyme cyclooxygenase-1 (COX-1), which is responsible for the synthesis of thromboxane A2 from arachidonic acid."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2744","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TRIFLUSAL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TRIFLUSAL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:08:27.210406","biosimilars":[],"competitors":[{"drugName":"clopidogrel","drugSlug":"clopidogrel","fdaApproval":"1997-11-17","genericCount":23,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticlopidine","drugSlug":"ticlopidine","fdaApproval":"1991-10-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acetylsalicylic acid","drugSlug":"acetylsalicylic-acid","fdaApproval":"1950-04-12","relationship":"same-class"},{"drugName":"dipyridamole","drugSlug":"dipyridamole","fdaApproval":"1961-12-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"epoprostenol","drugSlug":"epoprostenol","fdaApproval":"1995-09-20","patentExpiry":"Mar 15, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"iloprost","drugSlug":"iloprost","fdaApproval":"2004-12-29","patentExpiry":"Jul 18, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"abciximab","drugSlug":"abciximab","fdaApproval":"1993-12-16","relationship":"same-class"},{"drugName":"eptifibatide","drugSlug":"eptifibatide","fdaApproval":"1998-05-18","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tirofiban","drugSlug":"tirofiban","fdaApproval":"1998-05-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"treprostinil","drugSlug":"treprostinil","fdaApproval":"2002-05-21","patentExpiry":"Sep 5, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prasugrel","drugSlug":"prasugrel","fdaApproval":"2009-07-10","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cilostazol","drugSlug":"cilostazol","fdaApproval":"1999-01-15","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticagrelor","drugSlug":"ticagrelor","fdaApproval":"2011-07-20","patentExpiry":"Oct 17, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cangrelor","drugSlug":"cangrelor","fdaApproval":"2015-06-22","patentExpiry":"Nov 10, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"vorapaxar","drugSlug":"vorapaxar","fdaApproval":"2014-05-08","patentExpiry":"Dec 23, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"selexipag","drugSlug":"selexipag","fdaApproval":"2015-12-21","patentExpiry":"Oct 31, 2026","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"triflusal","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clopidogrel","brandName":"clopidogrel","genericName":"clopidogrel","approvalYear":"1997","relationship":"same-class"},{"drugId":"ticlopidine","brandName":"ticlopidine","genericName":"ticlopidine","approvalYear":"1991","relationship":"same-class"},{"drugId":"acetylsalicylic-acid","brandName":"acetylsalicylic acid","genericName":"acetylsalicylic acid","approvalYear":"1950","relationship":"same-class"},{"drugId":"dipyridamole","brandName":"dipyridamole","genericName":"dipyridamole","approvalYear":"1961","relationship":"same-class"},{"drugId":"epoprostenol","brandName":"epoprostenol","genericName":"epoprostenol","approvalYear":"1995","relationship":"same-class"},{"drugId":"iloprost","brandName":"iloprost","genericName":"iloprost","approvalYear":"2004","relationship":"same-class"},{"drugId":"abciximab","brandName":"abciximab","genericName":"abciximab","approvalYear":"1993","relationship":"same-class"},{"drugId":"eptifibatide","brandName":"eptifibatide","genericName":"eptifibatide","approvalYear":"1998","relationship":"same-class"},{"drugId":"tirofiban","brandName":"tirofiban","genericName":"tirofiban","approvalYear":"1998","relationship":"same-class"},{"drugId":"treprostinil","brandName":"treprostinil","genericName":"treprostinil","approvalYear":"2002","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02616497","phase":"PHASE4","title":"ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)","status":"COMPLETED","sponsor":"University of Ioannina","startDate":"2015-09","conditions":["Atherothrombosis"],"enrollment":1220,"completionDate":"2018-03-28"},{"nctId":"NCT02904109","phase":"PHASE2","title":"Influence of Triflusal on Cognitive Functions in Subjects Under Chronic Stress","status":"COMPLETED","sponsor":"Prof. Dominique de Quervain, MD","startDate":"2016-09-13","conditions":["Healthy"],"enrollment":41,"completionDate":"2017-02-28"},{"nctId":"NCT02321852","phase":"PHASE2","title":"Influence of Triflusal on Cognitive Functions in Healthy Subjects","status":"COMPLETED","sponsor":"Prof. Dominique de Quervain, MD","startDate":"2015-01","conditions":["Healthy"],"enrollment":40,"completionDate":"2015-11"},{"nctId":"NCT01174693","phase":"PHASE4","title":"Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2010-03","conditions":["Cerebral Infarction"],"enrollment":795,"completionDate":"2015-03"},{"nctId":"NCT01612273","phase":"PHASE4","title":"The Effect of Triflusal on Peripheral Microcirculation Dysfunction","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2011-04","conditions":["Vasospastic Syndrome"],"enrollment":92,"completionDate":"2013-06"},{"nctId":"NCT00162799","phase":"PHASE2","title":"Efficacy Pilot Study of Triflusal in the Attenuation of Insulin Resistance in Human Obesity","status":"COMPLETED","sponsor":"J. Uriach and Company","startDate":"2002-07","conditions":["Insulin Resistance"],"enrollment":30,"completionDate":"2004-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006012","UNII":"1Z0YFI05OO","CHEBI":"CHEBI:94721","INN_ID":"4266","RXNORM":"38655","UMLSCUI":"C0077126","ChEMBL_ID":"CHEMBL1332032","KEGG_DRUG":"D07142","DRUGBANK_ID":"DB08814","PUBCHEM_CID":"9458","SNOMEDCT_US":"698872000","MESH_SUPPLEMENTAL_RECORD_UI":"C016167"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":184,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"B01AC18","allCodes":["B01AC18"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triflusal is a small molecule used in clinical trials to study its effects on various conditions, including insulin resistance, atherothrombosis, and cerebral infarction. It has been tested in a randomized, placebo-controlled phase II crossover study to assess its influence on cognitive functions in healthy subjects.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}