{"id":"trifluridine-tipracil","safety":{"commonSideEffects":[{"rate":"30-40%","effect":"Diarrhea"},{"rate":"20-30%","effect":"Nausea"},{"rate":"10-20%","effect":"Vomiting"},{"rate":"10-20%","effect":"Fatigue"},{"rate":"5-10%","effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Trifluridine is a nucleoside analog that inhibits thymidylate synthase, an enzyme involved in DNA synthesis. Tipracil is a prodrug that is converted to 5-fluorouracil, which inhibits dihydrofolate reductase, another enzyme involved in DNA synthesis. This dual inhibition leads to the inhibition of DNA synthesis and cell death in rapidly dividing cells, such as cancer cells.","oneSentence":"Trifluridine/Tipracil is an antiviral drug that works by inhibiting thymidylate synthase and dihydrofolate reductase.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:09.222Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adenocarcinoma of the colon"}]},"trialDetails":[{"nctId":"NCT04879368","phase":"PHASE3","title":"RegoNivo vs Standard of Care Chemotherapy in AGOC","status":"ACTIVE_NOT_RECRUITING","sponsor":"Australasian Gastro-Intestinal Trials Group","startDate":"2021-06-01","conditions":"Gastro-Oesophageal Cancer","enrollment":450}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lonsurf"],"phase":"phase_3","status":"active","brandName":"Trifluridine/Tipracil","genericName":"Trifluridine/Tipracil","companyName":"Australasian Gastro-Intestinal Trials Group","companyId":"australasian-gastro-intestinal-trials-group","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trifluridine/Tipracil is an antiviral drug that works by inhibiting thymidylate synthase and dihydrofolate reductase. Used for Adenocarcinoma of the colon.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}