{"id":"trifluridine-cures","safety":{"commonSideEffects":[{"rate":null,"effect":"Neutropenia"},{"rate":null,"effect":"Anemia"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Gastrointestinal toxicity"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Trifluridine acts as a thymidine analog that inhibits thymidylate synthase, an enzyme critical for DNA synthesis. It is incorporated into DNA during replication, causing DNA damage and cell death in rapidly dividing cancer cells. This dual mechanism makes it effective against various malignancies.","oneSentence":"Trifluridine is a nucleoside analog that inhibits thymidylate synthase and gets incorporated into DNA, disrupting cancer cell replication.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:40:09.215Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic colorectal cancer"},{"name":"Gastric cancer"},{"name":"Pancreatic cancer"}]},"trialDetails":[{"nctId":"NCT06197425","phase":"PHASE3","title":"Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2024-01","conditions":"Colon or Upper Rectum Adenocarcinoma","enrollment":1660}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Trifluridine cures","genericName":"Trifluridine cures","companyName":"Centre Hospitalier Universitaire Dijon","companyId":"centre-hospitalier-universitaire-dijon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trifluridine is a small molecule DNA inhibitor used in cancer treatment. It has been studied in clinical trials for the treatment of colon or upper rectum adenocarcinoma, specifically in combination with other interventions such as FOLFIRI.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}