{"id":"trifarotene-0-005-topical-cream","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"},{"rate":"null","effect":"Dry skin"},{"rate":"null","effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By activating RAR-gamma, trifarotene influences the growth and differentiation of keratinocytes, which can help to reduce the severity of acne. This mechanism is thought to be responsible for the therapeutic effects of trifarotene in treating acne vulgaris.","oneSentence":"Trifarotene is a retinoic acid receptor gamma (RAR-gamma) agonist that modulates the expression of genes involved in cell differentiation and proliferation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:07.392Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT05550337","phase":"PHASE3","title":"Study Comparing Trifarotene Cream, 0.005% To AKLIEF ® (Trifarotene 0.005% Cream) In The Treatment Of Acne Vulgaris","status":"COMPLETED","sponsor":"Teva Pharmaceuticals USA","startDate":"2022-09-19","conditions":"Acne Vulgaris","enrollment":807}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Trifarotene 0.005 % Topical Cream","genericName":"Trifarotene 0.005 % Topical Cream","companyName":"Teva Pharmaceuticals USA","companyId":"teva-pharmaceuticals-usa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trifarotene is a retinoic acid receptor gamma (RAR-gamma) agonist that modulates the expression of genes involved in cell differentiation and proliferation. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}