{"id":"trichloroacetic-acid","rwe":[],"tags":[{"label":"trichloroacetic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Liquid","category":"form"},{"label":"Active","category":"status"},{"label":"Condyloma acuminatum","category":"indication"},{"label":"Caustics","category":"pharmacology"},{"label":"Noxae","category":"pharmacology"}],"phase":"discontinued","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"trichloracetic acid","offLabel":[],"synonyms":["trichloroacetic acid","trichloracetic acid","trichloroethanoic acid"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Trichloracetic Acid","ecosystem":[{"indication":"Condyloma acuminatum","otherDrugs":[{"name":"benzoin","slug":"benzoin","company":""},{"name":"cianidanol","slug":"cianidanol","company":""},{"name":"imiquimod","slug":"imiquimod","company":"Medicis"},{"name":"interferon alfa-2b","slug":"interferon-alfa-2b","company":"Schering"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"trichloroacetic acid","explanation":"When applied topically, trichloroacetic acid penetrates the outer layers of the skin and causes the infected cells to die, effectively removing the visible signs of the infection. This process is often referred to as 'chemical peeling.' The acid's ability to selectively target and destroy infected cells makes it an effective treatment for Condyloma acuminatum.","oneSentence":"Trichloroacetic acid works by directly destroying infected cells on the skin's surface.","technicalDetail":"Trichloroacetic acid exerts its therapeutic effect through a process of protein denaturation and cell lysis, resulting in the destruction of infected cells and the subsequent resolution of symptoms."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3627","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TRICHLOROACETIC%20ACID","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TRICHLOROACETIC ACID","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:02:20.397798","biosimilars":[],"competitors":[],"genericName":"trichloroacetic acid","indications":{"approved":[{"name":"Condyloma acuminatum","source":"DrugCentral","snomedId":240542006,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07060157","phase":"NA","title":"Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-07-22","conditions":["Melasma"],"enrollment":41,"completionDate":"2027-06-08"},{"nctId":"NCT07028567","phase":"NA","title":"Subcision Followed by Diluted Calcium Hydroxylapatite Injection Versus Subcision Followed by Painting CROSS TCA Technique for the Treatment of Atrophic Acne Scars","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-01-01","conditions":["Subcision","Calcium Hydroxylapatite","Trichloroacetic Acid","Atrophic Acne Scar"],"enrollment":13,"completionDate":"2023-06-22"},{"nctId":"NCT04429308","phase":"PHASE2","title":"PDT vs Peels for Treatment of Actinic Keratoses","status":"NOT_YET_RECRUITING","sponsor":"Northwestern University","startDate":"2025-08","conditions":["Actinic Keratoses"],"enrollment":60,"completionDate":"2026-12"},{"nctId":"NCT05471947","phase":"PHASE4","title":"TCA 15% Chemical Peel for Improvement in Hand Lentigines","status":"COMPLETED","sponsor":"Main Line Center for Laser Surgery","startDate":"2023-03-15","conditions":["Photoaging","Lentigo"],"enrollment":20,"completionDate":"2024-12-01"},{"nctId":"NCT06839638","phase":"NA","title":"Efficacy of 100% Trichloroacetic Acid Vs. 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Scars","status":"UNKNOWN","sponsor":"Shahid Beheshti University of Medical Sciences","startDate":"2006-03","conditions":["Atrophic Varicella Scar"],"enrollment":100,"completionDate":""}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Liquid","formulations":[{"form":"LIQUID","route":"TOPICAL","productName":"Trichloroacetic Acid 5%"}]},"crossReferences":{"NUI":"N0000147292","MMSL":"5620","NDDF":"002008","UNII":"5V2JDO056X","VUID":"4019018","CHEBI":"CHEBI:30956","VANDF":"4019018","RXNORM":"10773","UMLSCUI":"C0040900","ChEMBL_ID":"CHEMBL14053","PUBCHEM_CID":"6421","SNOMEDCT_US":"404881009","MESH_DESCRIPTOR_UI":"D014238"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5878,"therapeuticAreas":["Infectious 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It is used to treat Condyloma acuminatum, a sexually transmitted infection. The commercial status of trichloroacetic acid is unclear, but it is likely used as a generic medication. Key safety considerations include the potential for skin irritation and allergic reactions. Further research is needed to fully understand its pharmacokinetic properties.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}