{"id":"triamcinolone-pirfenidone","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Cough"},{"rate":"10-20%","effect":"Dyspnea"},{"rate":"10-20%","effect":"Fatigue"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Triamcinolone works by inhibiting the release of inflammatory mediators, such as histamine and bradykinin, from mast cells and other cells. Pirfenidone, on the other hand, has been shown to inhibit the proliferation of fibroblasts and the synthesis of collagen, which are key components of the extracellular matrix in fibrotic diseases.","oneSentence":"Triamcinolone is a corticosteroid that reduces inflammation, while pirfenidone is an antifibrotic that inhibits fibroblast proliferation and collagen synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:05.250Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Idiopathic pulmonary fibrosis"}]},"trialDetails":[{"nctId":"NCT02823236","phase":"PHASE3","title":"Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars","status":"UNKNOWN","sponsor":"Centro Dermatológico Dr. Ladislao de la Pascua","startDate":"2016-10-24","conditions":"Keloid","enrollment":102}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Kenalog + KitosCell"],"phase":"phase_3","status":"active","brandName":"Triamcinolone + Pirfenidone","genericName":"Triamcinolone + Pirfenidone","companyName":"Centro Dermatológico Dr. Ladislao de la Pascua","companyId":"centro-dermatol-gico-dr-ladislao-de-la-pascua","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triamcinolone is a corticosteroid that reduces inflammation, while pirfenidone is an antifibrotic that inhibits fibroblast proliferation and collagen synthesis. Used for Idiopathic pulmonary fibrosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}