{"id":"triamcinolone-acetonide-ta","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy (with topical use)"},{"rate":null,"effect":"Hypothalamic-pituitary-adrenal (HPA) axis suppression"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Immunosuppression and increased infection risk"},{"rate":null,"effect":"Osteoporosis (with chronic systemic use)"},{"rate":null,"effect":"Mood changes, insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Triamcinolone acetonide is a medium-to-long acting glucocorticoid that exerts anti-inflammatory and immunosuppressive effects by binding to intracellular glucocorticoid receptors, leading to altered gene transcription and reduced production of inflammatory cytokines and mediators. It inhibits phospholipase A2, reducing prostaglandin and leukotriene synthesis, and decreases immune cell migration and activation. The acetonide ester formulation provides sustained release and enhanced potency compared to the parent compound.","oneSentence":"Triamcinolone acetonide is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:14:28.886Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and allergic conditions (dermatitis, eczema, psoriasis)"},{"name":"Rheumatoid arthritis and other autoimmune disorders"},{"name":"Allergic rhinitis and asthma"},{"name":"Ocular inflammation"},{"name":"Oral lichen planus and other oral inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT07277998","phase":"NA","title":"Alternating Triamcinolone and Platelet-Rich Plasma Therapy for Oral Submucous Fibrosis","status":"NOT_YET_RECRUITING","sponsor":"Karachi Medical and Dental College","startDate":"2026-03","conditions":"Oral Submucous Fibrosis","enrollment":40},{"nctId":"NCT06478186","phase":"PHASE4","title":"Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes","status":"RECRUITING","sponsor":"University of Kansas Medical Center","startDate":"2024-08-16","conditions":"Osteoarthritis, Knee, Diabetes Mellitus, Type 2","enrollment":120},{"nctId":"NCT06314217","phase":"NA","title":"Everads Injector in Suprachoroidal Administration of TA Suspension, for Treatment of Patients With DME","status":"COMPLETED","sponsor":"Everads Therapy","startDate":"2024-02-18","conditions":"Diabetic Macular Edema","enrollment":10},{"nctId":"NCT06840561","phase":"PHASE2","title":"Local Triamcinolone Injection Combined With Fibrin Glue Spray in Preventing Esophageal Stricture After Big-range Endoscopic Submucosal Dissection for Esophageal Early Cancer","status":"COMPLETED","sponsor":"Sun Yat-Sen University Cancer Center","startDate":"2021-11-24","conditions":"Esophageal Stricture, Endoscopic Submucosal Dissection, Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection","enrollment":20},{"nctId":"NCT05806021","phase":"PHASE4","title":"The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis","status":"RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2024-01-15","conditions":"Primary Gonarthrosis","enrollment":327},{"nctId":"NCT05158699","phase":"PHASE3","title":"Effectiveness of Periocular Drug Injection in CATaract Surgery","status":"TERMINATED","sponsor":"Luigi Rondas","startDate":"2021-10-13","conditions":"Macular Edema, Cystoid Macular Edema, Retinal Disease","enrollment":628},{"nctId":"NCT03382262","phase":"PHASE2","title":"Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2017-12-18","conditions":"Osteoarthritis of the Shoulder, Osteoarthritis of the Hip","enrollment":55},{"nctId":"NCT03378076","phase":"PHASE2","title":"Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2017-12-06","conditions":"Bilateral Knee Osteoarthritis","enrollment":24},{"nctId":"NCT05893108","phase":"PHASE1, PHASE2","title":"Ethosomal Gel Bearing Losartan 5% for Keloid Treatment","status":"UNKNOWN","sponsor":"Yuni Eka Anggraini","startDate":"2024-03-30","conditions":"Keloid","enrollment":46},{"nctId":"NCT05939817","phase":"PHASE4","title":"The Effect of Intralesian Injection of Umbilical Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide on Type 1:3 Collagen Ratio and Interleukin-10 Levels in Keloid: A Randomised Controlled Trial","status":"COMPLETED","sponsor":"Rumah Sakit Pusat Angkatan Darat Gatot Soebroto","startDate":"2021-10-01","conditions":"Keloid, Stem Cell","enrollment":24},{"nctId":"NCT05887804","phase":"PHASE4","title":"Comparison of Keloid Volume and Symptoms Reduction Between Intralesional Umbilical-Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide Injection as Keloid Therapy: A Randomised Controlled Trial","status":"COMPLETED","sponsor":"Rumah Sakit Pusat Angkatan Darat Gatot Soebroto","startDate":"2021-10-01","conditions":"Keloid, Stem Cell","enrollment":24},{"nctId":"NCT05438277","phase":"PHASE4","title":"Pain Increases After Shoulder Injection","status":"COMPLETED","sponsor":"Campbell Clinic","startDate":"2020-01-01","conditions":"Shoulder Pain","enrollment":421},{"nctId":"NCT05345808","phase":"NA","title":"Efficacy of Formulated Posterior Sub Tenon Triamcinolone in Macular Edema Secondary to Non-Ischemic Retinal Vein Occlusions","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2021-03-01","conditions":"Retinal Vein Occlusion","enrollment":46},{"nctId":"NCT05271058","phase":"PHASE3","title":"Effect of Intracameral Steroids During Phacoemulsification on the Cornea","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-06-16","conditions":"Corneal Edema","enrollment":69},{"nctId":"NCT04782401","phase":"NA","title":"The Effects of Ultrasound Guided Genicular Nerve Block for Knee Osteoarthritis","status":"COMPLETED","sponsor":"Turkish League Against Rheumatism","startDate":"2020-03-01","conditions":"Knee Osteoarthritis","enrollment":102},{"nctId":"NCT05038072","phase":"NA","title":"The Use of Suprachoroidal Triamcinolone Acetonide to Treat Macular Edema in Retinal Vein Occlusion","status":"COMPLETED","sponsor":"Damascus University","startDate":"2019-07-25","conditions":"Macular Edema, Retinal Vein Occlusion","enrollment":16},{"nctId":"NCT03097315","phase":"PHASE3","title":"Suprachoroidal Injection of CLS-TA in Patients With Non-infectious Uveitis","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2017-04-04","conditions":"Uveitis, Uveitis, Posterior, Uveitis, Anterior","enrollment":38},{"nctId":"NCT02952001","phase":"","title":"MAGNOLIA: Extension Study of Patients With Non-infectious Uveitis Who Participated in CLS1001-301","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2017-12-13","conditions":"Uveitis, Uveitis, Posterior, Uveitis, Anterior","enrollment":33},{"nctId":"NCT02595398","phase":"PHASE3","title":"Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2015-11-17","conditions":"Uveitis, Uveitis, Posterior, Uveitis, Anterior","enrollment":160},{"nctId":"NCT02949024","phase":"PHASE1, PHASE2","title":"Suprachoroidal Injection of CLS-TA Alone or With Aflibercept in Subjects With Diabetic Macular Edema","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2016-11-10","conditions":"Diabetic Macular Edema","enrollment":20},{"nctId":"NCT03126786","phase":"PHASE2","title":"Suprachoroidal CLS-TA With Intravitreal Aflibercept Versus Aflibercept Alone in Subject With Diabetic Macular Edema","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2017-07-11","conditions":"Diabetic Macular Edema","enrollment":71},{"nctId":"NCT03203447","phase":"PHASE3","title":"Suprachoroidal Injection of Triamcinolone Acetonide With IVT Anti-VEGF in Subjects With Macular Edema Following RVO","status":"TERMINATED","sponsor":"Clearside Biomedical, Inc.","startDate":"2018-03-05","conditions":"Macular Edema, Retinal Vein Occlusion","enrollment":325},{"nctId":"NCT02980874","phase":"PHASE3","title":"Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO","status":"TERMINATED","sponsor":"Clearside Biomedical, Inc.","startDate":"2017-01-31","conditions":"Macular Edema, Retinal Vein Occlusion","enrollment":460},{"nctId":"NCT01789320","phase":"PHASE1, PHASE2","title":"Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2013-02","conditions":"Uveitis, Intermediate Uveitis, Posterior Uveitis","enrollment":11},{"nctId":"NCT02303184","phase":"PHASE2","title":"Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2015-01","conditions":"Macular Edema, Retinal Vein Occlusion","enrollment":46},{"nctId":"NCT02255032","phase":"PHASE2","title":"Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis","status":"COMPLETED","sponsor":"Clearside Biomedical, Inc.","startDate":"2014-10","conditions":"Uveitis, Macular Edema, Uveitis, Posterior","enrollment":22},{"nctId":"NCT04598542","phase":"PHASE1","title":"Drug-Drug Interaction Study of Lorecivivint and Triamcinolone Acetonide in Healthy Volunteers","status":"COMPLETED","sponsor":"Biosplice Therapeutics, Inc.","startDate":"2020-10-13","conditions":"Drug-Drug Interaction","enrollment":40},{"nctId":"NCT04627402","phase":"NA","title":"Effects of Adding Triamcinolone Acetonide to Conbercept Treatment for Refractory Diabetic Macular Edema (CONTE)","status":"UNKNOWN","sponsor":"Zhongshan Ophthalmic Center, Sun Yat-sen University","startDate":"2020-11-12","conditions":"Diabetes Mellitus, Type 2, Macular Edema","enrollment":50},{"nctId":"NCT04597060","phase":"NA","title":"The Safety and Efficacy of Thermo-mechanical System for Fractional Ablation Associated Triamcinolone Acetonide Drug Delivery for the Treatment of Hypertrophic Scars and Keloids","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2020-10","conditions":"Keloid","enrollment":25},{"nctId":"NCT04323982","phase":"NA","title":"Comparison of Traditional Cataract Surgery and Traditional Surgery Combined Triamcinolone Staining","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2020-03-27","conditions":"Congenital Cataract","enrollment":50},{"nctId":"NCT02806752","phase":"PHASE4","title":"Intravitreal Ranibizumab and TA Combination Therapy vs. Ranibizumab Monotherapy in Polypoidal Choroidal Vasculopathy","status":"UNKNOWN","sponsor":"Aier School of Ophthalmology, Central South University","startDate":"2017-01","conditions":"Wet Macular Degeneration","enrollment":120},{"nctId":"NCT02447185","phase":"PHASE3","title":"25-G Vitrectomy With Ranibizumab or Triamcinolone Acetonide on PDR in China-Randomized Clinical Trial","status":"UNKNOWN","sponsor":"JUNYAN ZHANG","startDate":"2015-06","conditions":"Proliferative Diabetic Retinopathy","enrollment":200},{"nctId":"NCT01774474","phase":"PHASE3","title":"PRevention of Macular EDema After Cataract Surgery","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2013-07-10","conditions":"Cystoid Macular Edema, Cataract, Diabetes Mellitus","enrollment":1127},{"nctId":"NCT02022930","phase":"PHASE3","title":"Hydros and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis","status":"COMPLETED","sponsor":"Carbylan Therapeutics, Inc.","startDate":"2014-01","conditions":"Osteoarthritis of the Knee","enrollment":510},{"nctId":"NCT01766609","phase":"PHASE2","title":"Efficacy and Safety of Intralesional Corticosterois in the Treatment of Vitiligo","status":"UNKNOWN","sponsor":"University of British Columbia","startDate":"2013-01","conditions":"Vitiligo","enrollment":18},{"nctId":"NCT01175395","phase":"PHASE1, PHASE2","title":"20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD)","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2010-09","conditions":"Age-Related Macular Degeneration, Choroidal Neovascularization","enrollment":10},{"nctId":"NCT00685490","phase":"","title":"Vitrectomy for Branch Retinal Vein Occlusion","status":"COMPLETED","sponsor":"Shinjo Ophthalmologic Institute","startDate":"1995-07","conditions":"Vitrectomy","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":959,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["kenalog"],"phase":"marketed","status":"active","brandName":"Triamcinolone Acetonide (TA)","genericName":"Triamcinolone Acetonide (TA)","companyName":"Rumah Sakit Pusat Angkatan Darat Gatot Soebroto","companyId":"rumah-sakit-pusat-angkatan-darat-gatot-soebroto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triamcinolone Acetonide is a small molecule that acts as a glucocorticoid receptor agonist. It is used to treat conditions such as macular edema, retinal vein occlusion, primary gonarthrosis, keloid, and is being studied in combination with stem cells for various indications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}