{"id":"triamcinolone-acetonide-ketorolac-ropivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (pain, swelling, erythema)"},{"rate":null,"effect":"Temporary numbness or paresthesia from local anesthetic"},{"rate":null,"effect":"Systemic corticosteroid effects (with repeated use)"},{"rate":null,"effect":"Gastrointestinal effects from ketorolac"}]},"_chembl":{"chemblId":"CHEMBL1504","moleculeType":"Small molecule","molecularWeight":"434.50"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Triamcinolone acetonide suppresses inflammatory responses by binding glucocorticoid receptors. Ketorolac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin-mediated inflammation and pain. Ropivacaine blocks sodium channels in nerve fibers to provide local anesthesia. Together, these agents provide multi-modal anti-inflammatory and analgesic effects at the injection site.","oneSentence":"This combination injection delivers a corticosteroid (triamcinolone acetonide) to reduce inflammation, a nonsteroidal anti-inflammatory drug (ketorolac) to inhibit prostaglandin synthesis and pain, and a local anesthetic (ropivacaine) to block nerve conduction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:04.463Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intra-articular or soft tissue injection for pain and inflammation associated with musculoskeletal conditions"}]},"trialDetails":[{"nctId":"NCT07151417","phase":"PHASE2, PHASE3","title":"Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Walter Reed National Military Medical Center","startDate":"2025-09-01","conditions":"Knee Osteoarthritis, Musculoskeletal Disease, Surgery","enrollment":240},{"nctId":"NCT07006168","phase":"PHASE4","title":"Effects Of Intra-Operative Intra-Articular Cocktail Injection In Patella Open Reduction And Internal Fixation","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2024-11-01","conditions":"Patella Fracture","enrollment":56},{"nctId":"NCT05336968","phase":"PHASE4","title":"Triamcinolone Ketorolac (TriKe) Knee Trial","status":"RECRUITING","sponsor":"United Health Services Hospitals, Inc.","startDate":"2022-09-15","conditions":"Osteoarthritis, Knee","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Triamcinolone acetonide-Ketorolac-Ropivacaine","genericName":"Triamcinolone acetonide-Ketorolac-Ropivacaine","companyName":"United Health Services Hospitals, Inc.","companyId":"united-health-services-hospitals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination injection delivers a corticosteroid (triamcinolone acetonide) to reduce inflammation, a nonsteroidal anti-inflammatory drug (ketorolac) to inhibit prostaglandin synthesis and pain, and a local anesthetic (ropivacaine) to block nerve conduction. Used for Intra-articular or soft tissue injection for pain and inflammation associated with musculoskeletal conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}