{"id":"triamcinolone-acetonide-indomethacin-cryotherapy-casting","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or cryotherapy-related tissue damage"},{"rate":null,"effect":"Gastrointestinal effects from indomethacin"},{"rate":null,"effect":"Systemic corticosteroid effects (with repeated use)"},{"rate":null,"effect":"Immobilization-related complications (atrophy, stiffness)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Triamcinolone acetonide reduces inflammation via glucocorticoid receptor activation. Indomethacin inhibits prostaglandin synthesis to further suppress inflammation and pain. Cryotherapy induces localized tissue necrosis and reduces metabolic activity in the treated area. Casting provides mechanical stabilization and immobilization to prevent further injury and promote healing.","oneSentence":"This is a multimodal treatment combining corticosteroid anti-inflammation (triamcinolone acetonide), nonsteroidal anti-inflammatory action (indomethacin), localized tissue destruction (cryotherapy), and mechanical immobilization (casting) for musculoskeletal or orthopedic conditions.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:14:30.876Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Musculoskeletal inflammatory conditions requiring local anti-inflammatory and immobilization therapy"}]},"trialDetails":[{"nctId":"NCT00554476","phase":"PHASE4","title":"Comparison of Two Combined Therapeutic Methods for Treatment of Lateral Epicondylitis","status":"TERMINATED","sponsor":"Azad University of Medical Sciences","startDate":"2003-01","conditions":"Lateral Epicondylitis","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Triamcinolone Acetonide- Indomethacin-Cryotherapy-Casting","genericName":"Triamcinolone Acetonide- Indomethacin-Cryotherapy-Casting","companyName":"Azad University of Medical Sciences","companyId":"azad-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a multimodal treatment combining corticosteroid anti-inflammation (triamcinolone acetonide), nonsteroidal anti-inflammatory action (indomethacin), localized tissue destruction (cryotherapy), and mechanical immobilization (casting) for musculoskeletal or orthopedic conditions. Used for Musculoskeletal inflammatory conditions requiring local anti-inflammatory and immobilization therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}