{"id":"tretoquinol","rwe":[],"tags":[{"label":"tretoquinol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-1 adrenergic receptor","category":"target"},{"label":"ADRB1","category":"gene"},{"label":"ADRB2","category":"gene"},{"label":"ADRB3","category":"gene"},{"label":"R03AC09","category":"atc"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"l-tretoquinol","offLabel":[],"synonyms":["tretoquinol","(S)-Trimetoquinol","L-Tretoquinol"],"timeline":[],"aiSummary":"L-Tretoquinol is a small molecule with the synonyms DL-TRIMETOQUINOL, INOLIN, NSC-288748, RACEMIC-TRIMETOQUINOL, RO-07-5965, and S-(-)-TRETOQUINOL. No specific information is available on its clinical indications or mechanism of action from the provided sources.","approvals":[],"brandName":"L-Tretoquinol","ecosystem":[],"mechanism":{"target":"Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Thromboxane A2 receptor","targets":[{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"},{"gene":"ADRB3","source":"DrugCentral","target":"Adrenergic receptor beta","protein":"Beta-3 adrenergic receptor"},{"gene":"TBXA2R","source":"DrugCentral","target":"Thromboxane A2 receptor","protein":"Thromboxane A2 receptor"}],"modality":"Small Molecule","drugClass":"tretoquinol","explanation":"Think of it like a key fitting into a lock. L-Tretoquinol is the key that binds to the Beta-1 adrenergic receptor, which is like a lock on the surface of heart cells. When the key fits into the lock, it sends a signal that can affect how the heart beats and how blood pressure is regulated.","oneSentence":"L-Tretoquinol works by binding to the Beta-1 adrenergic receptor, which is involved in regulating heart rate and blood pressure.","technicalDetail":"L-Tretoquinol acts as a selective agonist at the Beta-1 adrenergic receptor, activating the Gs protein-coupled signaling pathway to increase cAMP levels and stimulate cardiac contractility and heart rate."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2723","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TRETOQUINOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TRETOQUINOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:01:56.692896","biosimilars":[],"competitors":[{"drugName":"salbutamol","drugSlug":"salbutamol","fdaApproval":"1981-05-01","relationship":"same-class"},{"drugName":"terbutaline","drugSlug":"terbutaline","fdaApproval":"1974-03-25","genericCount":9,"patentStatus":"Off-patent — generic 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protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"tretoquinol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"salbutamol","brandName":"salbutamol","genericName":"salbutamol","approvalYear":"1981","relationship":"same-class"},{"drugId":"terbutaline","brandName":"terbutaline","genericName":"terbutaline","approvalYear":"1974","relationship":"same-class"},{"drugId":"isoetarine","brandName":"isoetarine","genericName":"isoetarine","approvalYear":"1979","relationship":"same-class"},{"drugId":"pirbuterol","brandName":"pirbuterol","genericName":"pirbuterol","approvalYear":"1986","relationship":"same-class"},{"drugId":"salmeterol","brandName":"salmeterol","genericName":"salmeterol","approvalYear":"1994","relationship":"same-class"},{"drugId":"formoterol","brandName":"formoterol","genericName":"formoterol","approvalYear":"2001","relationship":"same-class"},{"drugId":"clenbuterol","brandName":"clenbuterol","genericName":"clenbuterol","approvalYear":"","relationship":"same-class"},{"drugId":"bitolterol","brandName":"bitolterol","genericName":"bitolterol","approvalYear":"1984","relationship":"same-class"},{"drugId":"indacaterol","brandName":"indacaterol","genericName":"indacaterol","approvalYear":"2011","relationship":"same-class"},{"drugId":"olodaterol","brandName":"olodaterol","genericName":"olodaterol","approvalYear":"2014","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT00132925","phase":"PHASE3","title":"An Efficacy and Safety Evaluation of Nasacort AQ in Children Ages 2-5 Years With Perennial Allergic Rhinitis","status":"COMPLETED","sponsor":"Sanofi","startDate":"2003-11","conditions":["Rhinitis, Allergic, Perennial"],"enrollment":460,"completionDate":"2006-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"008209","UNII":"JIO3275WGI","CHEBI":"CHEBI:135461","INN_ID":"2648","UMLSCUI":"C0040846","ChEMBL_ID":"CHEMBL299175","KEGG_DRUG":"D08629","DRUGBANK_ID":"DB13692","PUBCHEM_CID":"656634","SNOMEDCT_US":"708662002","MESH_DESCRIPTOR_UI":"D014213"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"R03AC09","allCodes":["R03AC09","R03CC09"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}