{"id":"tretinoin-0-025-cream","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Erythema and irritation"},{"rate":"30-50","effect":"Peeling and dryness"},{"rate":"20-40","effect":"Photosensitivity"},{"rate":"20-30","effect":"Burning or stinging"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tretinoin acts as a ligand for nuclear retinoic acid receptors (RAR and RXR), which modulate transcription of genes involved in cell proliferation and differentiation. In the skin, it increases cell turnover, normalizes keratinization, and reduces follicular plugging. It also has anti-inflammatory properties and stimulates collagen remodeling, making it effective for both acne and photoaging.","oneSentence":"Tretinoin is a vitamin A derivative that binds to retinoic acid receptors to regulate gene expression, promoting cell differentiation and reducing sebum production and comedone formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:14:23.511Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Photoaging and fine wrinkles"},{"name":"Hyperpigmentation"}]},"trialDetails":[{"nctId":"NCT07345507","phase":"NA","title":"Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi","status":"COMPLETED","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2025-02-01","conditions":"Melasma","enrollment":34},{"nctId":"NCT06787222","phase":"PHASE2, PHASE3","title":"Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hasanuddin University","startDate":"2024-11-03","conditions":"Acne Vulgaris","enrollment":26},{"nctId":"NCT07154030","phase":"PHASE1","title":"Efficacy Of Combined Microneedling Plus Tretinoin In Treatment Of Stria Rubra","status":"NOT_YET_RECRUITING","sponsor":"Sohag University","startDate":"2025-09-05","conditions":"Striae","enrollment":300},{"nctId":"NCT07015931","phase":"PHASE1, PHASE2","title":"Efficacy, Safety Profile, and Post-Acne Sequelae of 0.025% Retinoic Acid Cream vs. 0.1% Adapalene Cream in Mild Acne Vulgaris in Fitzpatrick Skin Types III-V","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2024-11-30","conditions":"Acne Vulgaris","enrollment":23},{"nctId":"NCT06213987","phase":"PHASE3","title":"The Efficacy Tretinoin Cream in the Treatment of Axillary Hyperpigmentation Associated With Acanthosis Nigricans","status":"COMPLETED","sponsor":"Srinakharinwirot University","startDate":"2024-02-01","conditions":"Acanthosis Nigricans, Hyperpigmentation","enrollment":20},{"nctId":"NCT04724473","phase":"EARLY_PHASE1","title":"A Study Comparing Tretinoin Cream 0.025% and RETIN-A® Cream 0.025% in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2019-12-10","conditions":"Acne Vulgaris","enrollment":1030},{"nctId":"NCT01047189","phase":"PHASE4","title":"Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2009-03","conditions":"Acne Vulgaris","enrollment":26},{"nctId":"NCT01349556","phase":"NA","title":"Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin Cream","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2011-05","conditions":"Medication Reaction","enrollment":""},{"nctId":"NCT00974480","phase":"NA","title":"Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of Aging","status":"COMPLETED","sponsor":"Cosmetique Active International","startDate":"2009-09","conditions":"Skin Aging","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tretinoin"],"phase":"marketed","status":"active","brandName":"tretinoin 0.025% cream","genericName":"tretinoin 0.025% cream","companyName":"Wake Forest University","companyId":"wake-forest-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tretinoin is a vitamin A derivative that binds to retinoic acid receptors to regulate gene expression, promoting cell differentiation and reducing sebum production and comedone formation. Used for Acne vulgaris, Photoaging and fine wrinkles, Hyperpigmentation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}