{"id":"tree-12-sq-bet","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Ear pruritus"},{"rate":null,"effect":"Mild local swelling"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a sublingual immunotherapy (SLIT) tablet containing standardized tree pollen allergen extract, likely from multiple tree species. It works by inducing immune tolerance through repeated sublingual administration, shifting the immune response from Th2-mediated allergic reactions toward Th1/Treg-mediated tolerance. The mechanism involves gradual upregulation of regulatory T cells and IL-10 production, reducing allergic symptoms upon natural allergen exposure.","oneSentence":"Tree 12 SQ-Bet is an allergen immunotherapy product that desensitizes patients to tree pollen allergens through gradual exposure.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:14:18.816Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis and/or allergic asthma caused by tree pollen allergens"}]},"trialDetails":[{"nctId":"NCT05119751","phase":"PHASE4","title":"Vestibular Versus Sublingual Route of AIT Tablets","status":"COMPLETED","sponsor":"Clinique Spécialisée en Allergies de la Capitale","startDate":"2021-10-25","conditions":"Hypersensitivity","enrollment":172}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ITULATEK"],"phase":"marketed","status":"active","brandName":"tree 12 SQ-Bet","genericName":"tree 12 SQ-Bet","companyName":"Clinique Spécialisée en Allergies de la Capitale","companyId":"clinique-sp-cialis-e-en-allergies-de-la-capitale","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tree 12 SQ-Bet is an allergen immunotherapy product that desensitizes patients to tree pollen allergens through gradual exposure. Used for Allergic rhinitis and/or allergic asthma caused by tree pollen allergens.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}