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This mechanism is particularly effective against rapidly dividing cancer cells.","oneSentence":"Vincristine is a vinca alkaloid that binds to tubulin and disrupts microtubule formation, causing cell cycle arrest in metaphase and triggering apoptosis in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:02.206Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute lymphoblastic leukemia (ALL)"},{"name":"Hodgkin lymphoma"},{"name":"Non-Hodgkin lymphoma"},{"name":"Small cell lung cancer"},{"name":"Breast cancer"},{"name":"Testicular cancer"}]},"trialDetails":[{"nctId":"NCT04759586","phase":"PHASE3","title":"Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2021-10-05","conditions":"Primary Mediastinal Large B-Cell 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