{"id":"trazodone-pap-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"PAP device discomfort or mask-related irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Trazodone blocks serotonin reuptake and antagonizes serotonin 2A receptors, improving mood and sleep quality in patients with depression and insomnia. PAP therapy (CPAP, BiPAP, or APAP) delivers pressurized air to prevent airway collapse during sleep. This combination addresses both the psychiatric and respiratory components of sleep-disordered breathing in patients with comorbid depression and obstructive sleep apnea.","oneSentence":"Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that increases serotonin availability, combined with positive airway pressure (PAP) therapy to mechanically maintain open airways during sleep.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:05.702Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Obstructive sleep apnea with comorbid depression or insomnia"},{"name":"Sleep-disordered breathing in patients with major depressive disorder"}]},"trialDetails":[{"nctId":"NCT07210606","phase":"PHASE4","title":"Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment","status":"NOT_YET_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-10-01","conditions":"Sleep Disordered Breathing, Able Bodied","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Trazodone + PAP therapy","genericName":"Trazodone + PAP therapy","companyName":"VA Office of Research and Development","companyId":"va-office-of-research-and-development","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that increases serotonin availability, combined with positive airway pressure (PAP) therapy to mechanically maintain open airways during sleep. Used for Obstructive sleep apnea with comorbid depression or insomnia, Sleep-disordered breathing in patients with major depressive disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}