{"id":"travoprost-and-timolol","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Conjunctival hyperemia"},{"rate":"10-20","effect":"Eye irritation/discomfort"},{"rate":"5-15","effect":"Increased iris pigmentation"},{"rate":"5-10","effect":"Eyelash growth"},{"rate":"null","effect":"Bradycardia (systemic)"},{"rate":"null","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Travoprost binds to prostaglandin F (FP) receptors on the ciliary muscle and trabecular meshwork, enhancing drainage of aqueous humor through the uveoscleral pathway. Timolol blocks beta-2 adrenergic receptors in the ciliary body, reducing aqueous humor secretion. 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