{"id":"trastuzumab-pertuzumab","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Cardiotoxicity / left ventricular dysfunction"},{"rate":"5-15","effect":"Infusion reactions"},{"rate":"20-30","effect":"Diarrhea"},{"rate":"15-25","effect":"Nausea"},{"rate":"15-20","effect":"Fatigue"},{"rate":"10-15","effect":"Neutropenia"},{"rate":"10-15","effect":"Headache"}]},"_chembl":null,"_dailymed":{"setId":"27dd5e6b-72cd-458d-a015-cf4dab5800da","title":"PHESGO (PERTUZUMAB, TRASTUZUMAB, AND HYALURONIDASE-ZZXF) INJECTION, SOLUTION [GENENTECH, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Trastuzumab binds to domain IV of HER2, blocking ligand-independent signaling and promoting antibody-dependent cellular cytotoxicity. Pertuzumab binds to domain II of HER2, preventing heterodimerization with other HER family receptors. 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