{"id":"trastuzuma","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[{"effect":"Headache","drugRate":"10%","severity":"common","organSystem":""},{"effect":"Nasopharyngitis","drugRate":"8%","severity":"common","organSystem":""},{"effect":"Arthralgia","drugRate":"8%","severity":"common","organSystem":""},{"effect":"Diarrhea","drugRate":"7%","severity":"common","organSystem":""},{"effect":"Nausea","drugRate":"6%","severity":"common","organSystem":""},{"effect":"Pyrexia","drugRate":"6%","severity":"common","organSystem":""},{"effect":"Peripheral edema","drugRate":"5%","severity":"common","organSystem":""},{"effect":"Chills","drugRate":"5%","severity":"common","organSystem":""},{"effect":"Cough","drugRate":"5%","severity":"common","organSystem":""},{"effect":"Back pain","drugRate":"5%","severity":"common","organSystem":""},{"effect":"Asthenia","drugRate":"4.5%","severity":"common","organSystem":""},{"effect":"Ejection fraction decreased","drugRate":"3.5%","severity":"common","organSystem":""},{"effect":"Vomiting","drugRate":"3.5%","severity":"common","organSystem":""},{"effect":"Hypertension","drugRate":"4%","severity":"common","organSystem":""},{"effect":"Dizziness","drugRate":"4%","severity":"common","organSystem":""},{"effect":"Influenza","drugRate":"4%","severity":"common","organSystem":""},{"effect":"Myalgia","drugRate":"4%","severity":"common","organSystem":""},{"effect":"Rash","drugRate":"4%","severity":"common","organSystem":""},{"effect":"Palpitations","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Dyspnea","drugRate":"3%","severity":"common","organSystem":""}],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[{"effect":"Cardiac failure (congestive)","drugRate":"2%","severity":"serious"},{"effect":"Cardiac failure","drugRate":"0.5%","severity":"serious"},{"effect":"Interstitial pneumonitis","drugRate":"0.2%","severity":"serious"},{"effect":"Pulmonary hypertension","drugRate":"0.2%","severity":"serious"},{"effect":"Ventricular disorder","drugRate":"0.2%","severity":"serious"},{"effect":"Hypersensitivity","drugRate":"0.6%","severity":"serious"},{"effect":"Cardiac disorder","drugRate":"0.3%","severity":"serious"},{"effect":"Autoimmune thyroiditis","drugRate":"0.3%","severity":"serious"},{"effect":"Sudden death","drugRate":"0.06%","severity":"serious"},{"effect":"Asymptomatic cardiac dysfunction","drugRate":"8.1%","severity":"serious"}]},"trials":[],"_chembl":null,"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Trastuzuma","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T02:02:12.128507+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T02:02:18.461176+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Trastuzuma","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T02:02:18.861404+00:00"}},"offLabel":[],"timeline":[],"_dailymed":{"setId":"9a94f5b2-b84e-4987-8ea1-c4346db5a5fa","title":"KANJINTI (TRASTUZUMAB-ANNS) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [AMGEN, INC]"},"ecosystem":[],"mechanism":{"target":"Receptor tyrosine-protein kinase erbB-2, Tubulin beta"},"_scrapedAt":"2026-03-28T04:06:26.051Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"references":[],"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T02:02:21.025966+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"indications":{"approved":[{"name":"HER2-positive carcinoma of breast","diseaseId":"her2-positive-carcinoma-of-breast","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07470203","phase":"","title":"Pyrotinib Combined With Trastuzumab and Pertuzumab for Maintenance Therapy in HER2-Positive Advanced Breast Cancer","status":"NOT_YET_RECRUITING","sponsor":"Peking University Cancer Hospital & Institute","startDate":"2026-03-31","conditions":"HER2-positive Breast Cancer","enrollment":42},{"nctId":"NCT05975749","phase":"PHASE2","title":"Adjuvant Serplulimab and Trastuzuma and Chemotherapy in Her-2+ Gastric Cancer","status":"RECRUITING","sponsor":"Fudan University","startDate":"2023-01-01","conditions":"Gastric Cancer","enrollment":114}],"_emaApprovals":[],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"formularyStatus":[],"_approvalHistory":[],"developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"marketed","status":"active","brandName":"Trastuzuma","genericName":"Trastuzuma","companyName":"Fudan University","companyId":"fudan-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T02:02:21.025966+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":false,"indications":true,"safety":true,"trials":true,"score":3}}