{"id":"transdermal-therapeutic-system-melatonin","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Skin irritation at application site"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Melatonin is an endogenous hormone that acts as a circadian rhythm regulator by binding to melatonin receptors in the suprachiasmatic nucleus and other tissues. The transdermal therapeutic system formulation delivers melatonin across the skin to maintain steady-state plasma levels, enhancing sleep onset and quality. This mechanism helps restore normal sleep-wake cycles in patients with circadian rhythm disorders or insomnia.","oneSentence":"Melatonin binds to melatonin receptors (MT1 and MT2) to regulate circadian rhythm and promote sleep.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:50.894Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia"},{"name":"Circadian rhythm sleep disorders"},{"name":"Sleep disturbances"}]},"trialDetails":[{"nctId":"NCT02747628","phase":"PHASE4","title":"Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2013-04","conditions":"Postoperative Pain Relief","enrollment":60},{"nctId":"NCT02726126","phase":"","title":"Transdermal Fentanyl and Melatonin Patches for Postoperative Pain Relief","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2013-03","conditions":"Postoperative Pain","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TDM, melatonin sleep patch from Respro Labs ™ (7 mg/8hr)."],"phase":"marketed","status":"active","brandName":"transdermal therapeutic system- melatonin.","genericName":"transdermal therapeutic system- melatonin.","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Melatonin binds to melatonin receptors (MT1 and MT2) to regulate circadian rhythm and promote sleep. Used for Insomnia, Circadian rhythm sleep disorders, Sleep disturbances.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}