{"id":"transdermal-strogen","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Breast tenderness"},{"rate":"5-15%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-15%","effect":"Skin irritation at patch site"},{"rate":"5-10%","effect":"Vaginal bleeding or spotting"},{"rate":"5%","effect":"Fluid retention"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The patch formulation allows continuous, steady-state delivery of estradiol across the skin barrier into systemic circulation, bypassing first-pass hepatic metabolism. This provides more stable hormone levels compared to oral formulations and reduces fluctuations in estrogen exposure. The estrogen acts on estrogen receptors throughout the body to address symptoms and conditions related to estrogen deficiency.","oneSentence":"Transdermal estrogen delivers estradiol through the skin to replace or supplement endogenous estrogen levels.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:41.944Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes, night sweats)"},{"name":"Moderate to severe menopausal vulvar and vaginal atrophy"},{"name":"Hypoestrogenism and estrogen deficiency states"}]},"trialDetails":[{"nctId":"NCT01430650","phase":"PHASE4","title":"Endometrial Priming for Embryo Transfer","status":"COMPLETED","sponsor":"Parc de Salut Mar","startDate":"2010-07","conditions":"Sterility","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Transdermal strogen","genericName":"Transdermal strogen","companyName":"Parc de Salut Mar","companyId":"parc-de-salut-mar","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Transdermal estrogen delivers estradiol through the skin to replace or supplement endogenous estrogen levels. Used for Menopausal vasomotor symptoms (hot flashes, night sweats), Moderate to severe menopausal vulvar and vaginal atrophy, Hypoestrogenism and estrogen deficiency states.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}